Wang LL, Shan QW, Jiang HX, Tran DB, Qin X, Xie XZ, Liang DM. Detection of T lymphocyte subsets of children with Helicobacter pylori infection. World J Gastroenterol 2005; 11(18): 2827-2829 [PMID: 15884132 DOI: 10.3748/wjg.v11.i18.2827]
Corresponding Author of This Article
Professor Lin-Lin Wang, Department of Pediatrics, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wll276@yahoo.com.cn
Article-Type of This Article
Brief Reports
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Lin-Lin Wang, Qing-Wen Shan, Dan-Mei Liang, Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Hai-Xing Jiang, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Dinh-Binh Tran, Department of Microbiology, Hue Medical College, Hue City, Vietnam; Department of Pediatrics, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xue Qin, Medical Experimental Center of The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiang-Zhi Xie, Scientific Medical Experimental Center, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: All authors contributed equally to the work.
Supported by the Natural Science Foundation of Guangxi, No. 0135026
Correspondence to: Professor Lin-Lin Wang, Department of Pediatrics, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wll276@yahoo.com.cn
Telephone: +86-771-5356505 Fax: +86-771-5352523
Received: November 15, 2004 Revised: November 16, 2004 Accepted: November 24, 2004 Published online: May 14, 2005
Abstract
AIM: To study the transformation of T lymphocyte subsets in children with Heliobacter pylori (H pylori) infection.
METHODS: The H pylori infection status were determined by a combination of ELISA and Western blot (immunoblot) technique in 98 children and T lymphocyte subsets in peripheral blood were determined by flow cytometrical analysis.
RESULTS: There were 75 children positive with H pylori infection and 23 negative in 98 children. Comparing the proportion of peripheral blood T lymphocytic subsets in children with H pylori infection and without H pylori infection, it was found that a higher proportion of CD4 T-cells in infected children (39.02±7.71 vs 34.25±10.73, t = 2.246,P<0.05) and higher value of CD4 to CD8 T-cells ratio (1.51±0.52 vs 1.25, t = 2.104, P<0.05) were present, but there were not significant differences in CD3 T-cells and CD8 T-cells (73.11±10.02 vs 69.49±17.08, 27.22±6.07 vs 28.27±8.67, P>0.05).
CONCLUSION: Th1 cell-mediated immune responses may be induced by H pylori infection in children.
