Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

doi:10.3748/wjg.v10.i21.3146

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 1, 2004; 10(21): 3146-3150
Published online Nov 1, 2004. doi: 10.3748/wjg.v10.i21.3146

Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

Victor D. Pasechnikov, Sergey Z. Chukov, Sergey M. Kotelevets, Alexander N. Mostovov, Varvara P. Mernova, Maria B. Polyakova

Victor D. Pasechnikov, Sergey M. Kotelevets, Alexander N. Mostovov, Department of Therapy, Medical Academy, Stavropol, Russian Federation

Sergey Z. Chukov, Varvara P. Mernova, Maria B. Polyakova, Department of Pathology, Medical Academy, Stavropol, Russian Federation

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Victor D. Pasechnikov, Aviatsionnaya street, 21, Stavropol, 355017, Russian Federation. passetchnikov@mail.ru

Telephone: +7-8652-354700

Received: March 11, 2004
Revised: April 2, 2004
Accepted: April 9, 2004
Published online: November 1, 2004

Abstract

AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer.

METHODS: One hundred and seventy-eight consecutive Helicobacter pylori (H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity, specificity and prognostic values of the tests.

RESULTS: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17 or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic values.

CONCLUSION: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia, dysplasia or gastric cancer.

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