In 2016, the World Journal of Gastroenterology(WJG)has published the 33^rd issue which containing 20articles including one Frontier, 11 Reviews and eight Original Articles, contributed byscientists worldwide. Among these comprehensive articles are (1) “MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer”, a Frontier article by  Lynnette R Ferguson, Professor,et al fromDiscipline of Nutrition and Dietetics and Auckland Cancer Society Centre, Faculty of Medical and Health Science, The University of Auckland,New Zealand; (2) “Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni”, a Review article by Gireesh Rajashekara, DVM, PhD,et al from 170 Food Animal Health Research Program and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, United States; and (3) “Impact of Helicobacter pylori on the healing process of the gastric barrier”, a Basic Study by Magdalena Chmiela, PhD, Professor, et al from Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Poland, etc. We invite you to peruse all 20 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 22, Issue 33, September 7, 2016.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Yasuteru Kondo, MD, PhD, Assistant Professor, Gastroenterology, Tohoku University School of Medicine, Sendai 980-8574, Japan.

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue, at: http://www.wjgnet.com/1007-9327/e-journal.htm.