In 2019, the World Journal of Hepatology (WJH) has published the 4^th issue which containing 8 articles including 2 minireviews, 4 original articles, 1 case report, and 1 letter to the editor contributed by scientists worldwide. Among these comprehensive articles are (1) “MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma”, a minireviews by María Fernanda Troncoso, PhD, et al from Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Argentina; (2) “Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model”, a Basic Study by Vanessa Souza-Mello, Adjunct Professor, et al Instituto de Biologia Roberto Alcântara Gomes, Brazil; and (3) “Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible”, a Retrospective Study by Simona Jakab, MD, Associate Professor, et al Yale University School of Medicine, United States, etc. We invite you to peruse all 8 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 11, Issue 4, April 27, 2019.

Figure 1 The cover of the issue. Associate Editor of World Journal of Hepatology, Pietro Invernizzi, MD, PhD, Assistant Professor, Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano 20089, Italy.

We encourage hepatologists worldwide to submit manuscripts to the WJH describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.