In 2018, the World Journal of Gastroenterology (WJG) has published the 16^th issue which containing 10 articles including 4 reviews, and 6 original articles contributed by scientists worldwide. Among these comprehensive articles are (1) “Beneficial effects of naringenin in liver diseases: Molecular mechanisms”, a review by Pablo Muriel, PhD, Research Scientist, from Laboratory of Experimental Hepatology, Department of Pharmacology, Cinvestav-IPN, Mexico; (2) “Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction”, a basic study by  James L Trevaskis, PhD, Principal Scientist, et al from Cardiovascular and Metabolic Diseases, MedImmune, LLC, United States; and (3) “Papillary fistulotomy vs conventional cannulation for endoscopic biliary access: A prospective randomized trial”, a randomized clinical trial by Carlos Kiyoshi Furuya, MD, PhD, Medical Assistant, et al from Department of Gastrointestinal Endoscopy Unit, University of Sao Paulo, Brazil, etc. We invite you to peruse all 10 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 24, Issue 16, April 28, 2018.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Shu-You Peng, FRCS (Gen Surg), FRCS (Hon), MD, Professor, Surgeon, General Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue.