In 2016, the World Journal of Virology (WJV) has published the 4^th issue which containing 6 articles contributed by scientists worldwide. Among these comprehensive articles are (1) “Neurological manifestations of Zika virus infection”, a Review by Juan-Carlos Saiz, PhD, et al from the Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Spain; (2) “Regulation of Wnt/β-catenin signaling by herpesviruses”, a Minireviews by Deborah E Sullivan, PhD, Associate Professor, et al from Department of Microbiology and Immunology, Tulane University School of Medicine, United States; and (3) “Antiretroviral naive and treated patients: Discrepancies of B cell subsets during the natural course of human immunodeficiency virus type 1 infection”, an Original Article by Olga Tsachouridou, MD, PhD, et al from Research Associate of Infectious Diseases Unit, 1^st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, Greece, etc. We invite you to peruse all 6 articles in this issue, as they present the latest research progress/findings and provide insightful comments in virology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 5, Issue 4, November 12, 2016.

Figure 1 The cover of the issue. Editorial Board Member of World Journal of Virology, Jian-Qi Lian, MD, PhD, Associate Professor, Department of Infectious Diseases, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China

The WJV is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of virology. It was launched on February 12, 2012 and is published trimonthly (4 issues annually) by BPG, the world's leading professional clinical medical journal publishing company.

We encourage virologists worldwide to submit manuscripts to the WJV describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue, at: http://www.wjgnet.com/2220-3249/e-journal.htm.