Liu Yun 1. Personal Information Title/Position: Professor/ Vice President of the First Affiliated Hospital with Nanjing Medical University Correspondence Address: Department of Medical Information, School of Biomedical Engineering and Information, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China. E-mail: liuyun@njmu.edu.cn   2. Education and Employment Education INSTITUTION AND LOCATION DEGREE MM/YYYY SPECIALITY FIELD OF STUDY Nanjing Medical University B.S. 09/1984-07/1989 Medical Subjects Nanjing Medical University M.S. 09/1996-07/1999 Endocrinology Nanjing Medical University Ph.D. 09/2003-07/2006 Pharmacology Medical Center of Pittsburgh, PA, USA Postdoctoral 11/2007-12/2008 Endocrinology Employment DEPARTMENT AND INSTITUTION TITLE/POSITION MM/YYYY The Second Affiliated Hospital of Nanjing Medical University Resident Doctor，Attending Doctor 08/1989-07/2003 The Second Affiliated Hospital of Nanjing Medical University Associate Professor， Associate chief physician 08/2003-08/2006 The First Affiliated Hospital with Nanjing Medical University Associate Professor， Associate Chief Physician 09/2006-08/2009 The First Affiliated Hospital with Nanjing Medical University Assistant director of the Medical Department, Professor，Chief Physician 09/2009-04/2012 The First Affiliated Hospital with Nanjing Medical University Director of Information Department, Professor，Chief Physician 05/2012-07/2017 The First Affiliated Hospital with Nanjing Medical University Vice President, Professor，Chief Physician 08/2017- Present   3. Research Interests Medical Informatics; Obesity and diabetic mellitus; Insulin resistance.   4. 10 Selected Publications Yong Li,Kun Zhao,Hongcheng Wei,Wensen Chen,Wei Wang,Ling Jia,Qiongfang Liu,Jinpeng Zhang,Tao Shan,Zhihang Peng, Liu Y(Correspondent Author),Xiaoxiang Yan. Dynamic relationship between D-dimer and COVID-19 severity.2020 British Society for Haematology and John Wiley & Sons Ltd. Wenlong Ming,Hui Xie,Zixi Hu,Yuanyuan Chen,Yanhui Zhu,Yunfei Bai,Hongde Liu,Xiao Sun, Liu Y(Correspondent Author),Wanjun Gu.Two Distinct Subtypes Revealed in Blood Transcriptome of Breast Cancer Patients With an Unsupervised Analysis.Frontiers in Oncology,2019 October. Qianqian Chen, Hui Kong, Xu Qi , Wenqiu Ding, Ningfei Ji , Chaojie Wu, Chaolin Huang , Wenjuan Wu, Mao Huang1, Weiping Xie, Liu Y(Correspondent Author) and Jinhai Tang.Carcinoembryonic Antigen: A Potential Biomarker to Evaluate the Severity and Prognosis of COVID-19.Frontiers in Medicine 06 October 2020.（IF 3.900） Jingbao Kan,Cuiping zhao,Shan Lu,Geqian Shen,Jie Yang,Pei Tong,Ling Xi,Rihua Zhang,Xiubin Liang,Dongming Su,Dong Li, Liu Y(Correspondent Author). S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro. J Cell Physiol. 2019;1–12. Miao S, Xu T, Wu Y, Xie H, Wang J, Jing S, Zhang Y, Zhang X, Yang Y, Zhang X, Shan T, Wang L, Xu H, Wang S, Liu Y(Correspondent Author). Extraction of BI-RADS findings from breast ultrasound reports in Chinese using deep learning approaches. Int J Med Inform. 2018 Nov;119:17-21. Zhu W, Xue Y, Liang C, Zhang R, Zhang Z, Li H, Su D, Liang X, Zhang Y, Huang Q, Liu M, Li L, Li D, Zhao AZ, Liu Y(Correspondent Author). S100A16 promotes cell proliferation and metastasis via AKT and ERK cell signaling pathways in human prostate cancer. Tumour Biol. 2016 Sep;37(9):12241-12250. Zhang X, Wang L, Miao S, Xu H, Yin Y, Zhu Y, Dai Z, Shan T, Jing S, Wang J, Zhang X, Huang Z, Wang Z Guo J, Liu Y(Correspondent Author). Analysis of treatment pathways for three chronic diseases using OMOP CDM. J Med Syst. 2018 Nov 13;42(12):260. Liu Y, Ge ZP, Sun LZ, Tong P, Lu HM. Genetic variation of rs3811463 is associated with gestational diabetes mellitus susceptibility. Exp Ther Med. 2017 Nov;14(5):5157-5162. Wen-Sen Chen, Fu Qiao, Yue Yang, Xiao-Dong Gao, Zhan-Jie Li, Yong-Xiang Zhang, Wei-Hong Zhang, Qiang Fu,Liu Y(Correspondent Author). Interpretation and clinical practice of regulation for prevention and control of healthcare associated infection in outpatient and emergency department in healthcare facilities. Ann Transl Med. Dec 03, 2018 doi: 10.21037/atm.2018.12.05 Liu Y(Correspondent Author), Zhang R, Xin J, Sun Y, Li J, Wei D, Zhao AZ. Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells .Endocrinology. 2011;152(3):903-11. Epub 2011 Jan 25 Zhang R, Zhu W, Du X, Xin J, Xue Y, Zhang Y, Li D, Liu Y(Correspondent Author). S100A16 mediation of weight gain attenuation induced by dietary calcium.Metabolism. 2011 Aug 24. 2012，61（2）:157-163. Xin Zhang, Xiaoping Zhou, Xinyi Huang, ShumeiMiao, Hongwei Shan, Shenqi Jing, Tao Shan, Jianjun Guo, Jianqiu Kou, Zhongmin Wang, and Liu Y(Correspondent Author). The Analysis of the Disease Spectrum in China. BioMed Research International volume2014,601869 Dong Li, Rihua Zhang, Weidong Zhu, Yi Xue, Yuanyuan Zhang, Qiong Huang, Menglan Liu, Liu Y(Correspondent Author). S100A16 inhibits osteogenesis but stimulates adipogenesis. Molecular Biology Reports .2013;40(5): 3465-3473 . May 2013, Volume 40, Issue 5, pp 3465-3473 Xinli Du, Rihua Zhang, Yi Xue, Dong Li, Jinmei Cai, Suming Zhou, Zhengkai Huang, Rongbin Yu, Liu Y(Correspondent Author). Insulin glargine and risk of cancer: a meta-analysis Int J Biol Markers 2012; Oct 8;27(3):e241-6.   5. Research Projects As the host: 2018-2020，The establishment and demonstration application of diabetes information management platform and communication system, supported by grants from the National key Research & Development plan of Ministry of Science and Technology of the People’s Republic of China. 2016-2019, Construction and application of health big data Internet medical platform, supported by the 2016 industry prospecting and common key technology key projects of Jiangsu Province Science and Technology Department. 2019-2021, Platform construction and demonstration project of the smart ward, supported by Special project for provincial industrial and information industry transformation and upgrading in 2018. 2017-2019, Research on the construction standard and construction of health big data Internet medical platform, supported by Jiangsu provincial department of finance. 2017-2021, Construction and application of Internet platform for accurate diagnosis and treatment of chronic diseases based on big data, supported by Nanjing science bureau project. 2017, Pilot application of resident health card, supported by National health and family planning commission statistical information center project. 2014-2015, Jiangsu province nationwide intelligent medical remote emergency diagnosis and treatment information system for critical diseases phase I project, supported by Provincial development and reform commission project. 2015-2017, Integrated platform for intelligent medical treatment and cloud monitoring and diagnosis of chronic diseases, supported by Jiangsu province industrial and information industry transformation and upgrading project in 2015. 2013-2016, Studies on the role and mechanism of 11β-HSD1 and S100A16 in the regulation of adipocyte differentiation, supported by National natural science foundation of China. 2011-2013, The role of S100A16 gene in adipocyte differentiation and glycolipid metabolism, supported by National natural science foundation of China. 2011-2015, A novel adipocytokine S100A16 regulates adipocyte differentiation and improves insulin resistance, Jiangsu provincial health department xingwei project key individual project. 2011-2014, Establishment and application of an early warning system for abnormal glucose metabolism in community population, supported by Jiangsu science and technology support plan, social development project. 2014, The first batch of provincial coordinated infrastructure information network development and construction projects in 2014. 2011-2013, Epidemiological study on diabetes mellitus and metabolic syndrome in rural population, supported by open project of Shanghai diabetes key laboratory. 2014-2016, Medical platform application construction based on big data and Internet of things, supported by Jiangsu provincial health department.   And I am also Co-Investigator of the other projects supported by NSFC and provincial subjects.