Artificial intelligence and machine learning could support drug development for hepatitis A virus internal ribosomal entry sites

Table 1 Target and mechanism of anti-hepatitis A virus candidates

Target or mechanism	Drug	Ref.
La antigen	SD-1029, AG490	Jiang et al[34]
JAK2-STAT3	AZD1480	Jiang et al[35]
GRP78	Japanese rice-koji miso extracts	Shubin et al[50]; Choi et al[51]
GRP78	Zinc sulfate	Ogawa et al[52]
Inflammatory cytokines	Zinc chloride	Mo et al[53]

La: Lupus La protein/SSB; JAK: Janus kinase; STAT: Signal transducer and activator of transcription; GRP78: Glucose-regulated protein 78.