Review
Copyright ©The Author(s) 2021.
World J Meta-Anal. Jun 28, 2021; 9(3): 257-276
Published online Jun 28, 2021. doi: 10.13105/wjma.v9.i3.257
Table 1 Roles of Helicobacter pylori virulence factors on host immune response
Virulence factor
Effects over immune response
Ref.
CagAIL-8 stimulation; Suppression of proinflammatory cytokines through the inhibition of MAPK and NF-κBSchumacher and Schwarz[81] and Garlanda et al[83]
VacAInhibition of activation and proliferation of T and B cells; Induction of the apoptosis of macrophages (inhibition of INF-β signaling); IL-8 stimulation; Inhibition of IL-2 production by inhibiting NFAT; Impairment of antigen presentation by B lymphocytesDrici et al[86] Dinarello[89], Hollegaard and Bidwell[90], Sicinschi et al[91] and Garza-González et al[92]
DupAPromotion of neutrophilic infiltrationZeng et al[94]
OipAPromotion of neutrophilic infiltration; Stimulation of IL-1, IL-6, IL-8, IL-11, IL-17, MMP-1, TNF-α, and IRF-1Gehmert et al[97]
IceAStimulation of IL-1, IL-6, and IL-8Abbasian et al[101]
BabAStimulation of IL-33Xue et al[108]