Gadoxetic acid-enhanced magnetic resonance imaging for the detection of small hepatocellular carcinoma (≤ 2.0 cm) in patients with chronic liver disease: A meta-analysis

Table 1 Comparison of the diagnostic performance of Gadoxetic acid-enhanced magnetic resonance imaging alone and combined with diffusion weighted imaging¹

Diagnostic methods compared	Lesion size	Ref.	Summary sensitivity, % (95%CI)	Summary specificity, % (95%CI)
Gd-EOB-DTPA MRI alone	≤ 2.0 cm	[18,21,28]	0.77 (0.71-0.82)	0.97 (0.93-0.99)
Combined Gd-EOB-DTPA MRI with DWI			0.86 (0.82-0.90)	0.92 (0.88-0.96)
P value			0.0047	0.975
Gd-EOB-DTPA MRI alone	≤ 1.0 cm	[18,21]	0.56 (0.45-0.69)	0.96 (0.90-0.99)
Combined Gd-EOB-DTPA MRI with DWI			0.80 (0.68-0.88)	0.94 (0.87-0.98)
P value			0.0013	0.709

¹The diagnostic performance of each modality was compared by using the Z test for Summary sensitivity and specificity, P < 0.05 was considered indicative of a statistically significant difference. Gd-EOB-MRI: Gadoxetic acid-enhanced MRI; DWI: Diffusion-weighted imaging.