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©The Author(s) 2015.
World J Meta-Anal. Dec 26, 2015; 3(6): 295-303
Published online Dec 26, 2015. doi: 10.13105/wjma.v3.i6.295
Published online Dec 26, 2015. doi: 10.13105/wjma.v3.i6.295
Ref. | Arms | No. of patients | Male gender | Age (yr) | Child–Pugh Class (A/B/C) | Tumor size, cm | No. of tumors (1 vs ≥ 2) | Follow-up (mo) | OS rate (%) | RFS rate, % | ||||
1-yr | 3-yr | 5-yr | 1-yr | 3-yr | 5-yr | |||||||||
Zhang et al[9] | RFA + TACE | 15 | 12 | 57.8 ± 11.0 | -- | 4.6 ± 1.3 | -- | 24 | 100 | NA | NA | 92.3 | NA | NA |
(39-72) | (2.3-7.1) | |||||||||||||
RFA | 15 | 13 | 58.3 ± 12.7 | -- | 4.2 ± 1.1 | -- | 24 | 80 | NA | NA | -- | NA | NA | |
(38-78) | (2.4-6.0) | |||||||||||||
Shen et al[10] | IRFAPA | 18 | 5 | 52.7 | 4/14/0 | 5.6 | 0/18 | 28.3 | 87.5 | 52.2 | NA | 63.9 | 50.0 | NA |
(20-72) | (2.2-15.8) | (6-38) | ||||||||||||
RFA | 16 | 3 | 56.1 | 6/10/0 | 5.0 | 3/13 | 19.3 | 73.3 | 20.4 | NA | 30.0 | 18.7 | NA | |
(36-75) | (2.3-12.3) | (5-36) | ||||||||||||
Kang et al[11] | RRA + TACE | 19 | 14 | 52.2 | 12/7/0 | 6.7 ± 1.1 | -- | 36 | 84.2 | 36.8 | NA | -- | -- | NA |
RFA | 18 | 14 | 50.7 | 12/6/0 | 6.2 ± 1.2 | -- | 36 | 61.1 | 16.7 | NA | -- | -- | NA | |
Kobayashi et al[12] | RFA + AO | 10 | 7 | 67 | 4/5/1 | 1.7 | -- | 48 | -- | -- | NA | 87.5 | 25 | NA |
(50-76) | (1.0-2.4) | |||||||||||||
RFA | 10 | 8 | 63 | 3/5/2 | 2.3 | -- | 48 | -- | -- | NA | 70.0 | 20 | NA | |
(51-75) | (1.0-2.6) | |||||||||||||
Yang et al[13] | RFA + TACE | 31 | 23 | 60.3 ± 10.9 | -- | 6.5 ± 0.8 | -- | -- | 81.2 | -- | -- | -- | 82.2 | -- |
RFA | 12 | 8 | 61.0 ± 10.4 | -- | 5.2 ± 0.4 | -- | -- | 57.6 | -- | -- | -- | 65.3 | -- | |
Shibata et al[14] | RFA + TACE | 46 | 31 | 67.2 ± 8.9 | 32/14/0 | 1.7 ± 0.6 | 43/3 | 60 | 100 | 84.8 | -- | 71.3 | 48.8 | -- |
(45-83) | (0.9-3.0) | |||||||||||||
RFA | 43 | 33 | 69.8 ± 8.0 | 33/10/0 | 1.6 ± 0.5 | 42/1 | 60 | 100 | 84.5 | -- | 74.3 | 29.7 | -- | |
(44-87) | (0.8-2.6) | |||||||||||||
Morimoto et al[15] | RFA + TACE | 19 | 15 | 70 | 18/1/0 | 3.7 ± 0.6 | -- | 30 (12-46) | 100 | 93 | NA | 67 | -- | 9 |
(57-78) | ||||||||||||||
RFA | 18 | 12 | 73 | 16/2/0 | 3.6 ± 0.7 | -- | 32 (15-46) | 89 | 80 | NA | 56 | -- | 28 | |
(48-84) | ||||||||||||||
Peng et al[8] | RFA + TACE | 69 | 59 | 57.5 ± 10.0 | 60/9/0 | 2.1 ± 0.5 | 65/4 | 39.2 | 94 | 69 | 46 | 80 | 45 | 40 |
(19-75) | (0.8-5.0) | (5.0-95.0) | ||||||||||||
RFA | 70 | 55 | 55.1 ± 9.5 | 59/11/0 | 2.1 ± 0.4 | 65/5 | 33.6 | 82 | 47 | 36 | 64 | 18 | 18 | |
(22-75) | (0.9-5.0) | (2.0-87.0) | ||||||||||||
Peng et al[7] | RFA + TACE | 94 | 75 | 53.3 ± 11.0 | 90/4/0 | 3.5 ± 1.4 | 62/32 | 60 | 92.6 | 66.6 | -- | 79.4 | 66.7 | -- |
RFA | 95 | 71 | 55.3 ± 13.3 | 90/5/0 | 3.4 ± 1.4 | 67/28 | 60 | 85.3 | 59.0 | -- | 60.6 | 44.2 | -- |
Outcome | Potential modifiers | No. of studies | No. of events/patients | Heterogeneity test | RR (95%CI) | ||
RFA + TACE | RFA | ||||||
1-yr OS rate | Tumor size, cm | < 3 | 1 | 65/69 | 59/70 | NA | 1.12 (0.99, 1.26) |
3–5 | 3 | 121/128 | 109/128 | I2 = 0.0%, P = 0.66 | 1.11 (1.02, 1.21)1 | ||
> 5 | 3 | 57/68 | 30/46 | I2 = 0.0%, P = 0.80 | 1.28 (1.02, 1.61)1 | ||
Study location | China | 5 | 208/227 | 171/208 | I2 = 0.0%, P = 0.77 | 1.12 (1.04, 1.20)1 | |
Japan | 2 | 35/38 | 27/36 | I2 = 11.2%, P = 0.29 | 1.17 (0.96, 1.43) | ||
3-yr OS rate | Tumor size, cm | < 3 | 2 | 87/115 | 69/113 | I2 = 83.2%, P = 0.02 | 1.21 (0.79, 1.83) |
3–5 | 2 | 81/113 | 70/113 | I2 = 0.0%, P = 0.68 | 1.17 (0.99, 1.39)1 | ||
> 5 | 2 | 18/37 | 9/34 | I2 = 0.0%, P = 0.66 | 1.77 (0.95, 3.31) | ||
Study location | China | 3 | 122/181 | 95/181 | I2 = 18.7%, P = 0.29 | 1.29 (1.05, 1.58)1 | |
Japan | 3 | 64/84 | 53/79 | I2 = 33.4%, P = 0.22 | 1.12 (0.90, 1.39) | ||
1-yr | Tumor size, cm | < 3 | 3 | 102/125 | 88/123 | I2 = 10.7%, P = 0.33 | 1.11 (0.96, 1.28) |
RFS rate | 3–5 | 2 | 88/113 | 68/113 | I2 = 0.0%, P = 0.83 | 1.30 (1.09, 1.55)1 | |
> 5 | 1 | 11/18 | 5/16 | NA | 1.96 (0.87, 4.42) | ||
Study location | China | 3 | 141/181 | 108/181 | I2 = 0.0%, P = 0.55 | 1.29 (1.12, 1.49)1 | |
Japan | 3 | 60/75 | 53/71 | I2 = 0.0%, P = 0.70 | 1.04 (0.89, 1.23) | ||
3-year | Tumor size, cm | < 3 | 3 | 67/128 | 47/123 | I2 = 84.3%, P < 0.01 | 1.45 (0.59, 3.54) |
RFS rate | 3–5 | 1 | 63/94 | 42/95 | NA | 1.52 (1.16, 1.98)1 | |
> 5 | 2 | 34/49 | 11/28 | I2 = 51.0%, P = 0.15 | 1.56 (0.70, 3.47) | ||
Study location | China | 4 | 128/212 | 66/193 | I2 = 41.2%, P = 0.16 | 1.63 (1.19, 2.24)1 | |
Japan | 2 | 36/59 | 34/53 | I2 = 0.0%, P = 0.52 | 0.90 (0.71, 1.19) |
- Citation: Hu MZ, Li SF. Radiofrequency ablation with or without transarterial chemoembolization for hepatocellular carcinoma: A systematic review and meta-analysis. World J Meta-Anal 2015; 3(6): 295-303
- URL: https://www.wjgnet.com/2308-3840/full/v3/i6/295.htm
- DOI: https://dx.doi.org/10.13105/wjma.v3.i6.295