Risk factors associated with the development of chronic pouchitis following ileal-pouch anal anastomosis surgery for ulcerative colitis

Figure 1 Preferred Items for Systematic Reviews and Meta-Analysis flow diagram for the review. PRISMA: Preferred Items for Systematic Reviews and Meta-Analysis.

Figure 2  Risk of bias by domain of the included studies using the Risk of Bias In Non-Randomized Studies of Exposure Effects tool.

Figure 3 Meta-analysis and forest plots of studies assessing. A: Gender; B: Family history of ulcerative colitis; C: Smoking history; D: Extra-intestinal manifestations; E: Primary sclerosing cholangitis; F: Extent of colitis (pancolitis); G: Indication for surgery (refractory disease). EIM: Extra-intestinal manifestations; FHx: Family history; Pancol: Pancolitis; PSC: Primary sclerosing cholangitis; Refract: Refractory disease as indication for surgery; Smk: Smoking (current or ex-smoker).