Thyroid metastasis from breast cancer presenting with enlarged lateral cervical lymph nodes: A case report

Table 1 Reports of metastatic breast carcinoma involving the thyroid gland

Ref.	No of cases	Age (yr)	Type of BC	Location of BC	Location of TC	Time for metastasis (mo)	Metastases elsewhere	Immunohistochemistry	Treatment
Inic et al[1]	1	28	Lobular	Right	Bilateral	60	Lymph nodes in right lateral neck	Mammaglobin (+), GCDFP-15 (+), ER (+), PR (+), Tg (-), TTF-1 (-), CK7 (-) HER2 (-)	TT, right CLND and LLND
Liu et al[4]	1	47	Invasive ductal	Bilateral	Right	48	Bilateral cervical lymph nodes	ER (+), PR (+), HER2 (+)	Apatinib
Gong et al[6]	1	57	Metaplastic	Right	Left	24	NA	NA	NA
Zhou et al[7]	8	55.37	NA	Right (n = 5); left (n = 1); bilateral (n = 2)	NA	6 to 121	Chest wall (n = 2); supraclavicular nodes (n = 2); lung (n = 2); axilla nodes (n = 2); cervical and mediastinal lymph node (n = 2)	TG (-) and TTF-1 (-)	TT or lobectomy or chemotherapy
Ghias et al[8]	1	67	Invasive ductal	NA	Bilateral	24	Brain	AE1/AE3 (+), ER (+), GATA3 (+), E-cadherin (+), CK7 (-), CK20 (-), GCDFP/mammaglobin (-), TTF-1 (-), Tg (-), CT (-), synaptophysin (-)	Lobectomy
Yang et al[9]	1	51	Invasive ductal	Left	Left	288	Cervical lymph nodes	ER (+), PR (-)	TT with a selective LLND and postoperative chemotherapy
Owens et al[10]	1	64	Infiltrating mammary	NA	Left	60	Subcutaneous mass in the right shoulder and liver	HER2 (+)	No surgery
Magers et al[11]	1	37	Ductal breast	NA	Right lobe and isthmus	72	Bone and brain	GATA-3 (+), ER (+), PAX-8 (-), TTF-1 (-)	NA
Durmo et al[12]	1	72	Invasive ductal	NA	Left	NA	The third lumbar vertebrae and left iliac bone	NA	NA
Yang et al[13]	1	45	Infiltrating ductal	Right	Bilateral	36	Bilateral cervical lymph nodes	ER (+), PR (+), CerbB-2 (+), TTF-1 (-), Tg (-)	Bilateral subtotal thyroidectomy and lymphadenectomy
Zeng et al[14]	1	49	Inflammatory	Right	NA	7	Lymph nodes in right lateral neck	CA15-3 (+), Her2 (+++), GCDFP-15 (-), TG (-), TTF-1 (-), ER (-), PR (-)	TT, CLND, LLND and postoperative RAI and chemotherapy
Lacka et al[15]	1	54	Ductal-lobular mammary	Left	Bilateral	168	Skeletal supraclavicular lymph nodes, liver, and right lung	CKMNF 116 (+), CK7 (++), CEA (+), MGB2 (++), ER (+), PR (+), HER2 (+), CK20 (-), TG (-), TTF1 (-), CT (-), chromogranin (-)	TT and bilateral CLND and LLND with chemotherapy
Bourcier et al[16]	1	54	Invasive lobular	NA	left	0	Left supraclavicular and cervical lymph nodes	TG (-), TTF-1 (-), E-cadherin (-), HER-2 (-), AE1/AE3(+) ER (+), PR (+), CDX2 (+), PAX8 (+), GATA3(+)	TT and CLND
Pensabene et al[17]	1	64	Invasive lobular	Left	left	18	Bone	Cytokeratin-19 (+) ER (+) tireoglobulin (-), e-cadherin (-), cytokeratin-7 (-)	Lobectomy
Plonczak et al[18]	1	62	Invasive ductal	Bilateral	NA	144	Lung and bone, both lateral cervical lymph nodes	CEA (+), GATA3 (+), GCDFP-15 (+), CK7 (+), TG (-), TTF-1 (-), CK20 (-), PR (-), HER-2 (-)	TT and CLND

BC: Breast cancer; TC: Thyroid cancer; NA: Not available; TT: Total thyroidectomy; CLND: Central lymph node dissection; LLND: Lateral lymph node dissection; RAI: Radioactive ablation; TG: Thyroglobulin; ER: Estrogen receptor; PR: Progesterone receptor; Her-2: Human epidermal growth factor receptor 2; TTF-1: Thyroid transcription factor-1; CT: Calcitonin; CEA: Carcinoembryonic antigen; NA: Not available.