Lymphoepithelioma-like carcinoma of the upper urinary tract: A systematic review of case reports

Table 1 Clinicopathological characteristics of reported lymphoepithelioma-like carcinomas in the upper urinary tract

Case No.	Age/gender	Region	Presentation	Side	Location	Tumor stage	HC	CK antigen	EBV-status	Treatment	Follow-up in mo	Outcome	Ref.
1	73/F	Asia (Chinese Taipei)	Hematuria	Right	Renal pelvis	pT2N0M0	Pure	7	NM	RNU	24	NED	Chen et al[16], 2018
2	54/M	4 Europe (Spain); The remaining 6 unknown	Hematuria	NM	Ureter	pT3N1Mx	Predominant	7;20;CKAE1/AE3	Negative	RN + Ch	39	DWD	Lopez-Beltran et al[15], 2017
3	62/M		Hematuria	NM	Ureter	pT1N0Mx	Pure	7;20;CKAE1/AE3	Negative	RNU	55	NED	Lopez-Beltran et al[15], 2017
4	62/F		Hematuria	NM	Ureter	pT2N0Mx	Predominant	7;20;CKAE1/AE3	Negative	U	18	NED	Lopez-Beltran et al[15], 2017
5	80/F		Hematuria	NM	Ureter	pT3N0Mx	Pure	7;20;CKAE1/AE3	Negative	RNU	39	NED	Lopez-Beltran et al[15], 2017
6	76/M		Hematuria	NM	Ureter	pT3N1M0	Predominant	7;20;CKAE1/AE3	Negative	RNU + Ch	29	NED	Lopez-Beltran et al[15], 2017
7	61/M		Hematuria	NM	Ureter	pT1N0Mx	Pure	7;20;CKAE1/AE3	Negative	U	35	NED	Lopez-Beltran et al[15], 2017
8	64/M		Hematuria	NM	Renal pelvis	pT2N0Mx	Predominant	7;20;CKAE1/AE3	Negative	RN	58	NED	Lopez-Beltran et al[15], 2017
9	81/M		Hematuria	NM	Renal pelvis	pT3N1Mx	Predominant	7;20;CKAE1/AE3	Negative	RN+ Ch	7	DWD	Lopez-Beltran et al[15], 2017
10	85/M		Hematuria	NM	Renal pelvis	pT3N1Mx	Predominant	7;20;CKAE1/AE3	Negative	RN + Ch	4	DWD	Lopez-Beltran et al[15], 2017
11	81/M		Hematuria	NM	Renal pelvis	pT3N1M0	Predominant	7;20;CKAE1/AE3	Negative	RN + Ch	10	DWD	Lopez-Beltran et al[15], 2017
12	65/F	Asia (Korea)	Hematuria	Right	Renal pelvis	T3N0M0	Predominant	Cytokeratin	Negative	RN	6	NED	Ahn et al[17], 2014
13	61/M	Asia (China)	Flank pain; Hematuria	Left	Renal pelvis	T4N2M0	NM	7	Negative	RN	3	DWD	Liu et al[20], 2014
14	75/F	Europe (UK)	Flank pain; Hematuria	Right	Renal pelvis	T3N1M0	Predominant	20;AE1/AE3	NM	RNU	6	NED	Modi et al[14], 2013
15	64/M	Asia (Chinese Taipei)	Nausea	Right	Ureter	pT3N0M0	Pure	7	Negative	RNU	6	NED	Wen et al[25], 2012
16	76/F	Europe (Spain)	Recurrent UTI	Left	Ureter	T2N0M0	Pure	7;20;CKAE1/AE3	Negative	PN+U	5	NED	Val-Bernal et al[27], 2011
17	71/M	America (United States)	Hematuria	Right	Ureter	T2NxMx	Pure	7;20;CKAE1/AE3	Negative	RNU	5	NED	Allend et al[18], 2010
18	64/F	America (United States)	Hematuria	Left	Ureter	T2NxMx	Pure	7;CKAE1/AE3	Negative	U	24	NED	Ma et al[21], 2008
19	75/F	Asia (Japan)	Flank pain; Hematuria	Left	Renal pelvis	T1N1M0	Pure	Unknown	Negative	RNU	36	NED	Haga et al[26], 2007
20	75/F	Asia (Japan)	Flank pain; Hematuria	Left	Renal pelvis	T3N0M0	NM	15	Negative	RN	6	NED	Yamada et al[11], 2007
21	72/F	Europe or America	Incidental finding	NM	Renal pelvis	T3	Predominant	AE1/AE3	Negative	RN	3	DWD	Perez-Montiel et al[13], 2006
22	68/M	Europe or America	Incidental finding	NM	Renal pelvis	T3	Focal	AE1/AE3	Negative	RN	12	DWD	Perez-Montiel et al[13], 2006
23	73/M	Asia (Japan)	Hematuria	Right	Ureter	T2N0Mx	Pure	CKAE1/AE3	Negative	RNU	30	NED	Terai et al[24], 2005
24	58/M	Europe (Spain)	Hematuria	Left	Ureter	T3N0M0	Pure	CKAE1/AE3	Negative	RNU	18	NED	Roig et al[23], 2001
25	62/F	Asia (Chinese Taipei)	Hematuria	Right	Ureter	T2N0M0	Pure	CKAE1/AE 3	Negative	RNU	18	NED	Ng et al[22], 1999
26	79/F	Australia	Flank pain; Hematuria	Right	Renal pelvis	T3N0M0	NM	AE1/AE3	Negative	RNU	6	NED	Cohen et al[10], 1999
27	70/M	Asia (Japan)	Flank pain; Hematuria	NM	Renal pelvis	T1N0M0	Pure	7;20	Negative	RNU + RT	72	NED	Fukunaga et al[9], 1998
28	75/M	America (United States)	Hematuria	Right	Ureter	T3N0M0	Pure	7;20	Negative	U	12	NED	Chalik et al[19], 1998

Ch: Chemotherapy; CK: Cytokeratin; DWD: Died with disease; NED: No evidence of disease; EBV: Epstein-Barr virus; F: Female; HC: Histological classification; M: Male; NM: Not mentioned; PN: Partial nephrectomy; RNU: Radical nephroureterectomy; RN: Radical nephrectomy; RT: Radiotherapy; U: Ureterectomy; UTI: Urinary tract infection.

Table 2 Summary of clinicopathological patient characteristics

Variable	n (%), median (range)
Age in yr	72 (54-85)
Gender
Female	12 (42.9)
Male	16 (57.1)
Presentation
Hematuria	19 (67.9)
Pain	2 (7.1)
Hematuria and flank pain	3 (10.7)
Nausea	1 (3.6)
Recurrent UTI	1 (3.6)
Incidental finding	2 (7.1)
Side
Left	6 (21.4)
Right	9 (32.2)
NM	13 (46.4)
Location
Renal pelvis	14 (51)
Ureter	14 (50)
HC
Pure	14 (50)
Predominant	10 (35.7)
Focal	1 (3.6)
Unknown	3 (10.7)
Tumor stage
T1	4 (14.2)
T2	8 (28.6)
T3	15 (53.6)
T4	1 (3.6)
Treatment strategy
RNU-based therapy	13 (46.4)
Non RNU-based therapy	15 (53.6)
Follow-up in mo	15 (3-72)
Outcome
NED	21 (75)
DWD	7 (25)

DWD: Died with disease; HC: Histological classification; NM: Not mentioned; RN: Radical nephrectomy; RNU: Radical nephroureterectomy; UTI: Urinary tract infection.