Disseminated histoplasmosis in primary Sjögren syndrome: A case report

Figure 1 Brain magnetic resonance imaging. A: Diffusion-weighted imaging showed high signals (arrow) in the areas beside the frontal horn of the lateral ventricle; B: T2 weight imaging revealed slightly higher signal (arrow) in the areas beside the frontal horn of the lateral ventricle.

Figure 2 Bone marrow smear. Pathological findings (magnification, × 1000) of bone marrow demonstrated numerous yeast forms (black arrow) by Wright-Giemsa staining.

Figure 3 A simplified flow diagram of the histoplasmosis. When microconidia can effectively be inhaled and travel as far as the host alveoli, it can undergo the transition to yeast. Only when the H. capsulatum overcomes the mucosal barriers, effectively avoid host immune cell and effector responses, and multiply, can it cause host injury.