Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment

Table 1 Comparison of incubation period, duration and time until death of mice in each group

Groups (n = 10)	Variable group	Time (mean ± SD)	95%CI	P value
Normal saline control group	1	80.30 ± 22.32	64.33-96.27	-
Low-dose MgSO4 group	1	192.70 ± 73.57	140.07-245.33	0.174
Medium-dose MgSO4 group	1	380.20 ± 63.40b	334.85-425.55	< 0.01
High-dose MgSO4 group	1	1129.50 ± 252.51b	948.86-1310.14	< 0.01
Normal saline control group	2	25.80 ± 3.58	23.24-28.36	-
Low-dose MgSO4 group	2	81.10 ± 6.33b	76.57-85.63	< 0.01
Medium-dose MgSO4 group	2	70.20 ± 18.03b	57.30-83.10	< 0.01
High-dose MgSO4 group	2	75.20 ± 10.68b	67.56-82.84	< 0.01
Normal saline control group	3	30.10 ± 5.90	25.88-34.32	-
Low-dose MgSO4 group	3	83.10 ± 5.53b	79.15-87.05	< 0.01
Medium-dose MgSO4 group	3	86.50 ± 19.60b	72.48-100.52	< 0.01
High-dose MgSO4 group	3	111.70 ± 17.23b	99.37-124.03	< 0.01

^bP < 0.01, statistical differences are highly significant.

1: Incubation period (second); 2: Duration time (minute); 3: Survival time (minute). MgSO₄: Magnesium sulfate.

Table 2 Comparison of convulsion rate and mortality of mice in each group

Group	Convulsion rate (%)	H value	P value	Mortality rate (%)	H value	P value
Low-dose MgSO4 group	90	0.00	> 0.99	70	0.471	> 0.99
Medium-dose MgSO4 group	60	0.668	> 0.99	30	5.051	0.356
High-dose MgSO4 group	20	2.670	0.045a	10	9.899	< 0.01b

^aP < 0.05, differences are statistically significant.

^bP < 0.01, statistical differences are highly significant.

Control group: The control group in this study was the saline control group, in which mice received an equal volume of saline solution without magnesium sulfate. MgSO₄: Magnesium sulfate.