“Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis ― general presentation

Table 1 The 24 distinct real diagnoses of the tested group (as established by the medical doctor)

The real diagnoses of the tested group (as established by the medical doctor)	The number of tested cases per each real diagnosis (also in percents from the n = 34 patients in total) (%)	The indexed cases tested for each diagnosis in part
Viral diarrhea (rotavirus, norovirus, SARS-CoV2, adenovirus)	7 (21)	Cases No. 4, 5, 6, 14, 17, 19, 25
Bacterial diarrhea (Clostridium, Salmonella, Campylobacter, Shigella)	5 (15)	Cases No. 1, 5, 7, 14, 15, 18
Infectious mononucleosis (Epstein-Barr virus and/or citomegalovirus)	4 (12)	Cases No. 2, 23, 27, 34
Pyelonephritis (ESBL-neg./pos. E. coli)	4 (12)	Cases No. 4, 24, 29, 30
Viral URTI (adenovirus)	3 (9)	Cases No. 8, 25, 30
Iron-deficiency anemia	3 (9)	Cases No. 8, 15, 29
COVID-19 (both respiratory and digestive forms of COVID-19)	3 (9%)	Cases No. 10, 16, 19
Streptococcal pharyngitis/tonsillitis	2 (6)	Cases No. 3, 33
Viral encephalitis (varicella-zoster virus)	2 (6)	Cases No. 12, 22
Minor poststreptococcal inflammatory syndrome	1 (3)	Case No. 4
Viral pneumonia	1 (3)	Case No. 6
Hand-foot-and-mouth disease	1 (3)	Case No. 8
Type-A influenza	1 (3)	Case No. 9
Viral tracheobronchitis	1 (3)	Case No. 11
Bacterial acute otitis media	1 (3)	Case No. 11
Varicella	1 (3)	Case No. 12
Giardiasis (Giardia lamblia)	1 (3)	Case No. 13
Hepatitis A	1 (3)	Case No. 20
Floor-of-mouth abscess (sublingual gland abscess)	1 (3)	Case No. 21
Scarlet fever	1 (3)	Case No. 26
Acute lymphoblastic leukemia (ALL)	1 (3)	Case No. 28
Vulvovaginal (Vv.) candidiasis	1 (3)	Case No. 30
Marshall syndrome (PFAPA)	1 (3)	Case No. 31
Mediterranean spotted fever (Rickettsia conorii) (confirmed by pos. IgM anti-Rickettsia conorri)	1 (3)	Case No. 32

COVID-19: Coronavirus disease 2019.

Table 2 A simulation applied on a respiratory clinical and paraclinical picture example

A respiratory CPP example	The possible clusters that may partially or integrally explain the given respiratory CPP (%)	The possible diseases that may explain the possible clusters found by EPed
This CPP example contains these 7 listed signs (which are simultaneously processed as a single CPP	EPed has found many possible clusters that may partially explain the given respiratory CPP (the percent in parentheses represents the degree by which that specific cluster theoretically/potentially explains the given CPP	EPed has found many possible diseases that may explain the possible clusters found by EPed
Cough (“tuse”)	Systemic (biological) inflammatory syndrome (57%)	Tuberculosis (CSD = 1.1)
Fever (“febra”)	Systemic dissemination of Mycobacterium tuberculosis (42%)	Viral pneumonia (CSD = 1.1)
Wheezing (“wheezing”)	Broncho-esophageal fistula (42%)	Bacterial pneumonia (CSD = 1)
Increased erythrocyte sedimentation rate (ESR) (“VSH crescut”)	Tracheo-esophageal fistula (42%)	COVID-19 (CSD = 0.9)
Thrombocytopenia (“trombocitopenie”)	Bronchiolitis (a cluster defined by EPed as an inflammation of bronchioli) (28%)	Scarlet fever (CSD = 0.9)
Neutrophilia (“neutrofilie”)	Bronchiolitis obliterans (28%)	Acute viral diarrhea (CSD = 0.8)
Monocytosis (“monocitoza”)	Respiratory failure (28%)	Viral URTI (CSD = 0.8)
	Pericarditis (28%)	Bronchiolitis (CSD = 0.6)
	Functional respiratory syndrome of obstructive type (28%)	Measles (CSD = 0.5)
	Dehydration (28%)	Influenza (CSD = 0.5)
	Pleurisy (28%)	Congenital broncho-esophageal fistula (disease) (CSD = 0.5)
	Alveolar pneumonia (28%)	Congenital tracheo-esophageal fistula (disease) (CSD = 0.5)
	Interstitial pneumonia (28%)	Bacterial URTI (CSD = 0.4)
	Bronchitis (14%)	Infectious mononucleosis with EBV or/and CMV (CSD = 0.4)
	Carditis (pancarditis) (14%)	Cystic fibrosis (CSD = 0.4)
	Gastroesophageal reflux disease (14%)	Bacterial epiglottitis (CSD = 0.3)
	Rhinitis (a cluster defined by EPed as an inflammation of the nasal mucosa) (14%)	Viral laryngeal tracheitis (CSD = 0.2)
	Adenoiditis (a cluster defined by EPed as an inflammation of the nasal adenoids) (14%)	Periamygdalian abscess (phlegmon) (CSD = 0.2)
	Bacteremia (14%)	Cervical adenoflegmon (CSD = 0.2)
	Cholangitis (14%)	Asthma (CSD = 0.2)
	Endocarditis (14%)	Gastroesophageal reflux disease (CSD = 0.1)
	[…]	Hiatal hernia (CSD = 0.1)
	Pyelonephritis (14%)	etc.
	Sepsis (14%)
	Toxic bacterial syndrome (14%)
	SIRS (14%)
	CNS tuberculoma (14%)
	Viremia (14%)
	Hypersplenism (14%)
	Vasculitis (14%)
	etc.

CPP: Clinico-paraclinical picture; EPed: Electronic Pediatrician.