Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

doi:10.5662/wjm.v15.i1.98482

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Mar 20, 2025 (publication date) through Oct 1, 2024

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Mar 20, 2025; 15(1): 98482
Published online Mar 20, 2025. doi: 10.5662/wjm.v15.i1.98482

Table 1 Characteristics of study populations, n (%)/mean ± SD

Parameter		NMOSD group	MOGAD group	Control group
Average age (years)		39.6	36.9	36.9
Sex	Male	1 (12.5)	6 (35)	3 (30)
Sex	Female	7 (87.5)	11 (65)	7 (70)
Laterality	Unilateral	8 (100)	9 (53)	NA
Laterality	Bilateral	0 (0)	8 (47)	NA
Average visual acuity of affected eye at presentation (LogMAR)		2.42 ± 0.56	1.13 ± 0.86	NA
Average final visual acuity of affected eye (LogMAR)		0.77 ± 0.95	0.15 ± 0.25	NA

LogMAR: Logarithm of minimum angle of resolution; NMOSD: Neuromyelitis optica spectrum disorders; MOGAD: Myelin oligodendrocyte glycoprotein antibody disorder.

Table 2 Averages of collected data, mean ± SD

Variable measured	NMOSD group		MOGAD group		Control group
Variable measured	Affected eyes	Unaffected eyes	Affected eyes	Unaffected eyes	Healthy eyes
Average macular vascular density (mm/mm²)	16.6 ± 2.4	18.6 ± 3.3	16.0 ± 3.8	18.6 ± 1.4	31.8 ± 5.8
Average ganglion cell + inner plexiform layer thickness (micrometers)	52.4 ± 10.0	68.5 ± 7.9	53.1 ± 11.3	66.5 ± 5.4	69.67 ± 7.6

NMOSD: Neuromyelitis optica spectrum disorders; MOGAD: Myelin oligodendrocyte glycoprotein antibody disorder.

Table 3 Comparison of neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody disorder group with controls

Variable compared	P values
Variable compared	NMOSD affected eyes compared to controls	NMOSD unaffected eyes compared to controls	NMOSD affected eyes compared to NMO unaffected eyes	MOGAD affected eyes compared to controls	MOGAD unaffected eyes compared to controls	MOGAD affected eyes compared to MOGAD unaffected eyes	NMO affected eyes compared to MOGAD affected eyes	NMO unaffected eyes compared to MOGAD unaffected eyes
Macular vascular density	0.0002	0.0048	0.1228	0.0001	0.0012	0.3207	0.7814	0.6321
Average ganglion cell + inner plexiform layer thickness	0.0016	0.5398	0.0091	0.0003	0.0009	0.1472	0.8876	0.5622

NMOSD: Neuromyelitis optica spectrum disorders; MOGAD: Myelin oligodendrocyte glycoprotein antibody disorder.

Citation: Mahatme C, Kaushik M, Saravanan VR, Kumar K, Shah VM. Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis. World J Methodol 2025; 15(1): 98482
URL: https://www.wjgnet.com/2222-0682/full/v15/i1/98482.htm
DOI: https://dx.doi.org/10.5662/wjm.v15.i1.98482