Copyright
©The Author(s) 2021.
World J Methodol. Jul 20, 2021; 11(4): 130-143
Published online Jul 20, 2021. doi: 10.5662/wjm.v11.i4.130
Published online Jul 20, 2021. doi: 10.5662/wjm.v11.i4.130
Table 1 Summary of primary key proteins
Classification | Name | Function | Ref. |
Enzyme | DegP | Inhibiting EHEC biofilms. | [11] |
Enzyme | Llp1, Llp2 | Inhibiting biofilm formation of pathogen. | [12] |
Enzyme | Protease of S. boulardii | Digesting both C. difficile toxin A and its receptor binding sites. | [15] |
Enzyme | Lon protease | Degrading the oncogene c-MYC. | [19] |
Secreted protein | P9 | Inducing the secretion of GLP-1. Inducing the secretion of IL-6 in macrophages. | [21,22] |
Secreted protein | Peptide B7 | Reducing CCR2 expression on all APCs from health people. | [25] |
Secreted protein | MAM | Inhibiting the NF-κB pathway and several cell immune responses. Inducing expression of TGF β. | [26-28] |
Surface layer protein | MIMP | Inducing the secretion of anti- inflammatory cytokines and inhibiting inflammatory cytokines. Enhancing the intestinal barrier. | [29] |
Enzyme | OGA | Hydrolysing O-GlcNAcylated NF-κB-p65 and IKKβ to inhibit NF-κB signaling. | [30] |
Bacteriocins | PediocinPA-1/AcHnisin Z | Reducing colonization of VRE in vivo. | [38] |
Microcin | limiting the expansion of pathogens. | [39,40] | |
Bacteriocins | Enterocins | Inhibiting a wide spectrum of Gram-positive bacteria. Inhibiting the growth of cancer cells. | [42,43] |
Bacteriocins | Bacteriocin A, B | Degrading pathogenic biofilm and having antibacterial potential. | [36] |
Bacteriocins | Nisin A | Changing the integrity of the cancer cell membrane. | [44] |
Secreted protein | P8 | Inducing host cell growth arrest at the G2 phase. | [46,47] |
Ribosomal proteins | HPRP-A1; HPRP-A2 | Resisting infection. Arresting the cancer cells cycle at the G0/G1 phase and G2/M phase. | [48-53] |
Innermembrane protein | Pre-FadA | Binding host epithelial cells. | [54] |
Secreted protein | m-FadA | Inducing the invasion of host cells. | [54] |
Outer membrane protein | Fap2 | Leading to colonization of Fn. Facilitating tumor immunity evasion. Binding to and activating TIGIT. Inducing host lymphocyte apoptosis. | [55-57] |
Secreted proteins | OMVs of Fn | Inducing the colonization of host epithelial cells. | [58-60] |
Cell envelope-associated multiprotein systems | Sus-like systems | Inducing the colonization of host epithelial cells. | [64] |
Pili | SpaCBA | Inducing the adhesion of mucus. | [66,67] |
Secreted proteins | EVs | Inducing the expression of the TJ protein-encoding genes and regulating the intestinal barrier. Inducing the expression of PPARα and PPARγ genes and ANGPTL4 gene. Inhibiting blood lipase lipoproteins in the bloodstream. | [71,72] |
Secreted proteins | TcpC OMVs of EcN | Enhancing epithelial barrier. | [77-81] |
Table 2 Summary of secondary key proteins
Classification | Name | Function | Ref. |
Flagellin | Inducing the secretion of proinflammatory cytokines. | [87] | |
Flagellin | Recuiting flagellin specific CD4+ T-cells. | [85] | |
Flagellin | Inducing the secretion of flagellin antibodies. | [88,89] | |
Flagellin | Inducing the secretion of AMPs. | [90] | |
Flagellin | Inducing the secretion of human β-defensin 2. | [91] | |
Flagellin | Inducing the expression of lncRNA (HIF1A-AS2) and suppressing NF-kB signaling pathway activation. | [92] | |
Outer membrane protein | OmpC, OmpW | Adhesion and invasion of the CD-associated Escherichia coli in intestinal epithelial cells. Cross-reactive bacterial proteins. | [95-97] |
Outer membrane protein | FomA | Inducing upregulation of CD86, MHC II, and primary B cells. Inducing secretion of antigen-specific antibody IgA and IgG. | [99,100] |
Bacterial division protein | FtsZ | Cross-reacting with TBB-5 and mediating the secretion of p-ANCA. | [102,103] |
Bacterial heat shock protein | GroEL | Cross-reacting with Hsp60 and inducing antibodies. | [110,111] |
- Citation: Zeng XY, Li M. Looking into key bacterial proteins involved in gut dysbiosis. World J Methodol 2021; 11(4): 130-143
- URL: https://www.wjgnet.com/2222-0682/full/v11/i4/130.htm
- DOI: https://dx.doi.org/10.5662/wjm.v11.i4.130