Maintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors

Figure 1 The sequence alignment of human ZFX (top) and ZFY (bottom). Protein BLAST for two sequences (https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins&PROGRAM=blastp&BLAST_PROGRAMS=blastp&PAGE_TYPE=BlastSearch&BLAST_SPEC=blast2seq&DATABASE=n/a&QUERY=&SUBJECTS=) was used.

Figure 2 The schematic figure summarizes the potential self-renewal signaling driving c-Myc expression. A: Direct control of c-Myc expression by ZFX; B: Indirect control of c-Myc expression through canonical Wnt/-catenin signaling. ZFX first binds the consensus sequence upstream of the Wnt3a gene to induce the expression of the Wnt3a protein. Secreted Wnt3a binds to its receptor by either autocrine or paracrine. TCF/LEF: T-cell factor/lymphoid enhancer factor.