Pain reduction and adverse effects of intravenous metoclopramide for acute migraine attack: A systematic review and meta-analysis of randomized-controlled trials

Figure 1  PRISMA flow chart of study selection.

Figure 2  Cochrane risk of bias assessment of included studies.

Figure 3  Details of each domain of Cochrane risk of bias assessment.

Figure 4 Forest plot comparing pain reduction at 60 min between intravenous metoclopramide and other drugs. CI: Confidence interval; IV: Intravenous; SC: Subcutaneous.

Figure 5 Forest plot comparing pain reduction at 60 min between intravenous metoclopramide and placebo. CI: Confidence interval; IV: Intravenous.

Figure 6 Forest plot comparing odds ratios of adverse effects between intravenous metoclopramide and other drugs. CI: Confidence interval; IV: Intravenous.

Figure 7 Forest plot comparing odds ratios of adverse effects between intravenous metoclopramide and placebo. CI: Confidence interval; IV: Intravenous.

Figure 8 Funnel plot of pain reduction at 60 min between intravenous metoclopramide and other drugs. IV: Intravenous; SC: Subcutaneous; SE: Standard error; SMD: Standard mean difference.