Khokhar RK, Nashwan AJ. Gut virome and its emerging role in inflammatory bowel disease. World J Methodol 2025; 15(3): 100534 [DOI: 10.5662/wjm.v15.i3.100534]
Corresponding Author of This Article
Abdulqadir J Nashwan, PhD, Researcher, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Sep 20, 2025; 15(3): 100534 Published online Sep 20, 2025. doi: 10.5662/wjm.v15.i3.100534
Gut virome and its emerging role in inflammatory bowel disease
Rahat Khatoon Khokhar, Abdulqadir J Nashwan
Rahat Khatoon Khokhar, Department of Medicine, People’s University of Medical and Health Sciences, Nawabshah 67450, Pakistan
Abdulqadir J Nashwan, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Doha 3050, Qatar
Author contributions: Khokhar RK and Nashwan AJ were responsible for writing the draft and critically reviewing the literature.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdulqadir J Nashwan, PhD, Researcher, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Received: August 19, 2024 Revised: January 20, 2025 Accepted: February 6, 2025 Published online: September 20, 2025 Processing time: 199 Days and 4.7 Hours
Abstract
Inflammatory bowel disease (IBD) is a progressive multifactorial inflammatory disease of the gut. The cause of IBD is yet unknown. Some researchers have shown that genetic factors, environmental factors, and the gut microbiome are significant considerations. Our gut contains gut virome and gut bacteria, which vary among individuals due to some factors. The gut virome is a substantial component of the microbiome. This editorial explores the emerging role of gut virome in IBD.
Core Tip: Inflammatory bowel disease (IBD) is a chronic multifactorial inflammatory disease involving the gastrointestinal tract. The exact etiopathogenesis is unknown, but gut microbiome dysbiosis is believed to be a cornerstone in triggering disease progression. The gut virome forms a significant part of the microbiome and participates in health and disease conditions. Until 2015, researchers paid little attention to their role in IBD. Subsequently, numerous studies have followed this line of inquiry, using advanced techniques to clarify this role. Herein, we emphasize the viral populations in the gut and their predicted roles in the etiopathogenesis of IBD based on current studies.
