Through the last decades, our research was focused on several major areas of organ pathophysiology. Unravelling the mechanism(s) of drugs, environmental pollutants and nanostructure induced cell injury and death in multiple vital target organs and exploration of the antitoxic/antioxidant potentials of natural and man-made antioxidants in the prevention and/or amelioration of the organ dysfunction was our major contribution in this field. We made many breakthroughs while studying on natural bioactive compounds like arjunolic acid, taurine, mangiferin, etc. Specifically, we hold a pioneer position in studying the broad spectrum activity of arjunolic acid (Recently Sigma Aldrich Co has launched this product and cited a number of the publications of this study) and that of the non-essential amino acid, taurine. Detail studies on the mechanism of the protective actions of these molecules clearly suggest their excellent hepatoprotective, cardioprotective and renoprotective activities without any detectable side effects and could provide a new promising solution to very serious and potential pathophysiological situations. Along with these achievements, our contribution in the field of diabetic pathophysiology is highly appreciable. We proposed detailed mechanism of the protective action of natural antioxidants (arjunalic acid, taurine, D-saccharic acid 1,4-lactone and mangiferin) on the detrimental effects of oxidative stress in diabetic pathophysiology and its associated complications. This study might help researcher to design potential therapeutics against diabetes in future and relief common people from the burden of expensive commercially available drugs. We have also contributed an excellent quality of research on the environmentally exposed nanostructure-induced organ pathophysiology and its reversal. Applying detail mechanistic approach, we showed that nano copper particles could induce liver and kidney dysfunctions and cellular damage Moreover, we are also working on the preparation of mesoporous silica nanoparticles (MSNs) and intend to devise a targeted anti-cancer therapy by loading those MSNs with potent anticancer natural bioactive compounds and believe that these findings will help the researchers further to assess the worse impact of these nano materials and also help to find suitable remedies. Our research has been highly recognized in the scientific community worldwide as evidenced from the H-index (79), i-10-index (185) and citations (16622) of our publications (300) in the journals of high international repute (Google Scholar Citation Report).