Copyright
©The Author(s) 2015.
World J Transl Med. Dec 12, 2015; 4(3): 69-77
Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.69
Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.69
Table 1 Small molecules targeting apoptosis for cancer therapy
| Drug name | Mechanism of action | Drug targets |
| CP-31398 | Restoration of wild type p53 function | Mutant p53 |
| PRIMA-1 | Restoration of wild type p53 function | Mutant p53 |
| Nutlins | Prevent p53 degradation | p53/MDM2 |
| RITA | Prevent p53 degradation | p53/MDM2 |
| Oblimersen sodium | Antisense inhibitors | Bcl-2 |
| ABT-737 | BH3 mimetics | Bcl-2, Bcl-XL,Bcl-w |
- Citation: Liu XC, Gao JM, Liu S, Liu L, Wang JR, Qu XJ, Cai B, Wang SL. Targeting apoptosis is the major battle field for killing cancers. World J Transl Med 2015; 4(3): 69-77
- URL: https://www.wjgnet.com/2220-6132/full/v4/i3/69.htm
- DOI: https://dx.doi.org/10.5528/wjtm.v4.i3.69