Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients

Table 1 Baseline clinical and laboratory data for 146 patients with chronic kidney disease¹

Baseline clinical	Laboratory data
Age (yr)	61.7 ± 15.24
Female sex	62 (41.89%)
Systolic blood pressure (mmHg)	131.18 ± 13.2
Diastolic blood pressure (mmHg)	75.27 ± 10.51
Body mass index (kg/m2)2	24.99 ± 4.7
Hemoglobin (g/dL)	11.14 ± 2.16
BUN (mg/dL)	43.16 ± 23.56
Cr (mg/dL)	3.63 ± 3.19
eGFR-MDRD (mL/min per 1.73 m2 of Body surface area3)	38.13 ± 35.24
CRP (mg/L)	0.223 ±0.362
Ferritin (μg/mL)	254.59 ± 293.41
Iron (μg/dL)	74.6 ± 37.95
TSAT-percent4	0.28 ± 0.15
Albumin (g/dL)	3.96 ± 0.59
Fasting blood sugar (mg/dL)	116.9 ± 41.48
Uric acid (mg/dL)	7.71 ± 1.91
Calcium (mg/dL)	8.9 ± 0.56
Phosphate (mg/dL)	4.2 ± 1.57
Intact PTH (pg/mL)	291.97 ± 473.35
Total cholesterol (mg/dL)	176.31 ± 39.2
LDL cholesterol (mg/dL)	108.37 ± 35.8
HDL cholesterol (mg/dL)	49.35 ± 15.8
Triglycerides (mg/dL)	129.07 ± 73.96
IL-6 (ng/mL)	722.37 ± 205.53
Hepcidin (ng/mL)	19.42 ± 5.68

¹Data given are the mean ± SD;

²The body mass index is the weight in kilograms divided by the square of the height in meters;

³The estimated glomerular filtration rate was calculated according to the Modification of Diet in Renal Disease formula: 186 × [serum creatinine (in micromoles per liter)/88.4] -1.154 × age (in years) -0.203 × 1.21 (if patient is black) × 0.742 (if patient is female);

⁴The percent transferrin saturation was calculated as iron/total iron binding capacity (TIBC). BUN: Blood urea nitrogen; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol; IL-6: Interleukin-6; PTH: Parathyroid hormone; CRP: C-reactive protein; TSAT: Transferrin saturation; Cr: Chromium; eGFR: Estimated glomerular filtration rate.

Table 2 Correlation of the serum hepcidin level with 2D echocardiography parameters in the multivariate analysis

Serum hepcidin level	r	P-value
LVMI	-0.514	0.0051
LVM	-0.402	0.0411
IVSd	-0.135	0.265
LVPW	-0.226	0.062
RVD	0.033	0.789
LA	0.015	0.904
EF	-0.018	0.882

All measurements were obtained using standard procedures: parasternal long axis view, parasternal short axis view, apical four-chamber view and apical five-chamber view.

¹P <0.05 was considered statistically significant. LVM: Left ventricular mass; LVMI: Left ventricular mass index; IVSd: Interventricular septum thickness; LVPW: Left ventricular posterior wall thickness; RVD: Right ventricular dimension; EF: Ejection fraction; LA: Left atrium.