Species differences in regulation of renal proximal tubule transport by certain molecules

Figure 1 Species differences in thiazolidinediones effects on proximal tubule transport. Non-genomic activation of ERK by TZDs via PPARγ/Src/EGFR pathway is suppressed in mouse proximal tubule probably due to constitutive activation of Src/EGFR. TZDs: Thiazolidinediones; PPAR: Peroxisome proliferator activated receptor; Src: Sarcoma; EGFR: Epidermal growth factor receptor; ERK: Extracellular signal-regulated kinase.

Figure 2 Species differences in angiotensin II effects on proximal tubule transport. In human, NO/cGMP pathway mediates the concentration-dependent stimulatory effect of Ang II. In other species, NO/cGMP pathway mediates the inhibitory effect of high concentrations of Ang II. Ang II: Angiotensin II; NO: Nitrox oxide; cGMP: Guanosine 3',5'-cyclic monophosphate; cGKII: cGMP-dependent kinase II; ERK: Extracellular signal-regulated kinase.