Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules

doi:10.5527/wjn.v3.i3.77

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Aug 6, 2014 (publication date) through Feb 15, 2025

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Aug 6, 2014; 3(3): 77-84
Published online Aug 6, 2014. doi: 10.5527/wjn.v3.i3.77

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Figure 1 Molecules constituting the slit diaphragm. Nephrin and NEPH1 are the transmembrane proteins constituting the extracellular site of the slit diaphragm. Nephrin interacts with CD2 associated protein (CD2AP), podocin and NEPH1. NEPH1 interacts with ZO-1. Canonical transient receptor potential-6 (TRPC6) is located at the slit diaphragm area. SV2B is expressed at the slit diaphragm area and contributes to the proper localization of CD2AP. Ephrin-B1 and neurexin are transmembrane proteins of the slit diaphragm. GBM: glomerular basement membrane; ZO-1: Zonula occludens-1.

Citation: Fukusumi Y, Miyauchi N, Hashimoto T, Saito A, Kawachi H. Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules. World J Nephrol 2014; 3(3): 77-84
URL: https://www.wjgnet.com/2220-6124/full/v3/i3/77.htm
DOI: https://dx.doi.org/10.5527/wjn.v3.i3.77