Review
Copyright ©2013 Baishideng.
World J Nephrol. Feb 6, 2013; 2(1): 1-10
Published online Feb 6, 2013. doi: 10.5527/wjn.v2.i1.1
Figure 1
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Figure 1 Schematic view of podocyte structure. A: Cytoskeleton; B: Apical membrane domain; C: Slit diaphragm protein complex domain; D: Basal membrane domain. Adaptor proteins link mainly slit diaphragm proteins to cytoskeleton. FAKs: Focal adhesion kinases; ZO: Zonula occludens; CD2AP: CD2-associated protein.
Figure 2
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Figure 2 Nephrin-adaptors complex. Adaptor proteins including CD2-associated protein (CD2AP) and Nck, anchor nephrin and podocin to the cytoskeleton, maintain podocyte cytoskeletal structure and modulate the signaling pathway between the slit diaphragm and cytoskeleton. PI3-K: Phosphoinositide 3-kinase; N-WASP: Neuronal Wiskott-Aldrich syndrome protein.
Figure 3
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Figure 3 P-Cadherin-β-catenin-Wnt signaling. Wnt/β-catenin signaling plays an important role in cell adhesion, maintaining the cytoskeletal structure and survival/apoptosis in podocytes. ZO: Zonula occludens; CD2AP: CD2-associated protein.