Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease: Real practice experience

Figure 1 Box and whisker plot (with dots) comparing the baseline measured glomerular filtration rate and estimated by the chronic kidney disease epidemiology collaboration, the modification of diet in renal disease, and creatinine clearance formulas. Measured glomerular filtration rate by modification of diet in renal disease was significantly different than that estimated by creatinine clearance (P < 0.05). No significant differences were observed among the other methods. CKD-EPI: Chronic kidney disease epidemiology collaboration; CrCl: Creatinine clearance; MDRD: Modification of diet in renal disease; mGFR: Measured glomerular filtration rate.

Figure 2 Bland-Almant plot of study sample. A: Bland-Almant plot of study sample comparing the measured glomerular filtration rate (mGFR) and the estimated glomerular filtrataion rate (eGFR) assessed by different formulas; B: Bland-Almant plot of study sample comparing the changes between baseline and month-6 mGFR and the eGFR assessed by different formulas. The mean score is plotted on the x-axis, and the difference between observers (mean of the differences) is plotted on the y-axis (mean difference ± 1.96 SD). Dark circles represent the patients with a baseline mGFR ≤ 80 mL/minute. The empty squares represent the patients with a baseline mGFR > 80 mL/minute. mGFR: Measured glomerular filtration rate.

Figure 3 Absolute differences between measured and estimated month-6 glomerular filtration rates changes vs baseline measured glomerular filtration rates. There was no any relationship between the estimated glomerular filtration rates regardless the formula and the baseline measured glomerular filtration rates. mGFR: Measured glomerular filtration rate.