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World J Nephrol. Jul 25, 2022; 11(4): 115-126
Published online Jul 25, 2022. doi: 10.5527/wjn.v11.i4.115
Figure 1
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Figure 1 Membranous nephropathy. Old classification of membranous nephropathy. PLA2R: Phospholipase A2 receptor; THSD7A: Thrombospondin type 1 domain containing 7A.
Figure 2
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Figure 2 Structure of neural epidermal growth factor-1 protein. TSPN: TSP-1-like domain; C-C: Coiled coil domain; VWC: Von Willebrand factor type C domain; EGF: EGF-like domains E.
Figure 3
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Figure 3 Structure of Semaphorin. Sema: Sema domain; PSI: Plexin-semaphorin-integrin; Ig: Immunoglobulin.
Figure 4
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Figure 4 Distribution of podocyte antigens in patients with ‘primary’ membranous nephropathy. PLA2R: Phospholipase A2 receptor; THSD7A: Thrombospondin type 1 domain containing 7A; NELL-1: Neural epidermal growth factor-like 1 protein; Sema: Sema domain.
Figure 5
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Figure 5 Patient distribution according to antigen and presence of associated disease. AD: Associated disease; NSAID: Nonsteroidal anti-inflammatory drug; EXT: Exostosin; MN: Membranous nephropathy; NCAM-1: Neural cell adhesion molecule 1; NELL-1: Neural epidermal growth factor like-1 protein; PCDH7: Protocadherin; PLA2R: Phospholipase A2 receptor; SEMA 3B: Semaphorin 3B; THSD7A: Thrombospondin type 1 domain containing 7A.
Figure 6
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Figure 6 New proposed classification of membranous nephropathy. PLA2R: Phospholipase A2 receptor; THSD7A: Thrombospondin type 1 domain containing 7A; NELL-1: Neural epidermal growth factor-like 1 protein; Sema: Sema domain; PCDH7: Protocadherin 7; EXT: Exostosin; NCAM-1: Neural cell adhesion molecule 1.
Figure 7
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Figure 7 Schematic classification of different conditions leading to membranous nephropathy. PLA2R: Phospholipase A2 receptor; THSD7A: Thrombospondin type 1 domain containing 7A; NELL-1: Neural epidermal growth factor-like 1 protein; Sema: Sema domain; PCDH7: Protocadherin 7; EXT: Exostosin; NCAM-1: Neural cell adhesion molecule 1; MN: Membranous nephropathy.