Treatment of dyslipidemia in chronic kidney disease: Effectiveness and safety of statins

Figure 1 Diagram of the lecithin: cholesterol acyltransferase reaction[18]. Cholesterol acyltransferase (LCAT) cleaves the fatty acid (R2) from the sn-2 position of phosphatidylcholine and then transesterifies it to the A-ring of cholesterol, producing lysophosphatidylcholine and cholesteryl ester. CE: Cholesteryl ester; CETP: Cholesteryl ester transfer protein; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; TG: Triglyceride; SR-BI: Scavenger receptor class B type I.

Figure 2 The impact of atorvastatin on the activity of lecithin: Cholesterol acyltransferase enzymes of high-density-lipoprotein remodelling[21]. LCAT: Cholesterol acyltransferase. ^aP < 0.05.

Figure 3 Protein isoprenylation and “pleiotropic” effects of statins[63-65]. HMG-CoA: 3-hydroxy-methyl-glutaryl-Coenzyme A.