Retrospective study evaluating association of colorectal tumors and hepatitis C virus

Table 1 Patient demographics, n (%)

Variables	HCV (n = 109)	Non-HCV (n = 97)	OR	95%CI	P value
Age (mean ± SD)	62.73 ± 9.14	60.20 ± 7.06			0.0261
Female gender	48 (44)	46 (47.4)	0.872	0.504-1.511	0.6263
Ethnicity					0.4273
Caucasian	81 (74.3)	84 (86.6)	0.447
Hispanic	18 (16.5)	11 (11.3)	1.546
Asian	4 (3.7)	2 (2.1)	1.809
African American	4 (3.7)	0
Others	2 (1.8)	0
BMI > 25	28.0 (7)	32.0 (7)			0.0011,2
Aspirin intake	22 (20.2)	35 (36.1)	0.448	0.24-0.83	0.0111,3
Smoking history			2.31	1.31-4.07	0.0041,2
Non-smoker	51 (46.8)	65 (67)
Current smoker	38 (34.9)	15 (15.5)
Former smoker	20 (18.3)	17 (17.5)
Total pack year, median (IQR)	25 (7)	25 (7)			0.7572
DM	27 (24.8)	31 (32)	0.872	0.50-1.51	0.253
Adenomatous polyps	58 (53.2)	33 (34)	2.206	1.25-3.876	0.0061,3
Bowel preparation					0.1483
Good	90 (82.6)	88 (90.7)	0.484
Fair	11 (10.1)	7 (7.2)	1.443
Poor	8 (7.3)	2 (2.1)	3.762

¹Statistically Significant.

²Mann Whitney U test.

³χ² test.

HCV: Hepatitis C virus; BMI: Body mass index; OR: Odds ratio; IQR: Interquartile range; CI: Confidence interval; DM: Diabetes mellitus.

Table 2 Bivariate logistic regression for colonic adenoma

Patient characteristics	P value	OR	95%CI for OR
			Lower	Upper
Age (> median)	0.56	1.18	0.66	2.12
Presence of HCV	0.0191	2.07	1.12	3.81
Aspirin intake	0.06	0.51	0.25	1.04
Smoking history	0.49	1.22	0.67	2.23
Female gender	0.86	1.05	0.58	1.88
Diabetes mellitus	0.52	1.24	0.63	2.45

¹Statistically significant.

HCV: Hepatitis C virus; OR: Odds ratio.

Table 3 Polyp characteristics and location in hepatitis C virus patients and non-hepatitis C virus patients, n (%)

Polyp characteristics	HCV	Non-HCV
Number of polyps	88 (60.27)	58 (39.72)
Polyp size < 5 mm	59 (67.04)	38 (65.51)
Range of polyp size (mm)	1-30	1-18
Histopathology of lesions:
Tubular Adenoma	58 (74.6)	38 (74.4)
Hyperplastic	28 (23.7)	18 (23.1)
Cancer	2 (1.7)	0
Inflammatory	0	2 (2.5)
Location:
Right colon	29 (32.9)	14 (24.1)
Left colon	17 (19.3)	9 (15.5)
Transverse colon	14 (15.9)	14 (24.1)
Sigmoid colon	20 (22.7)	8 (13.7)
Rectum	8 (9.09)	13 (22.4)

HCV: Hepatitis C virus.

Table 4 Genotype distribution among hepatitis C virus patients, n (%)

HCV genotype	With adenoma (n = 58)	Without adenoma (n = 51)
1a	37 (63.7)	28 (54.9)
1b	6 (10.3)	11 (21.5)
2b	3 (5.1)	2 (3.9)
3	8 (13.7)	9 (17.6)
4	4 (6.8)	0
6	0	1 (1.9)

HCV: Hepatitis C virus.

Table 5 Il28 gene polymorphism in hepatitis C virus patients, n (%)

Il28 gene polymorphism	HCV patients
CC	37 (33.9)
CT	61 (56)
TT	11 (10.1)

HCV: Hepatitis C virus.

Table 6 Covariate adjustment for colonic adenoma post propensity score matching

Patient characteristics	OR	P value	Standard error
Hepatitis C	1.89	0.03141	0.33
Age	1.04	0.02951	0.01
Female gender	1.02	0.9428	0.31
BMI	1.00	0.9164	0.02
Aspirin intake	0.38	0.01161	0.37
Smoking history	0.95	0.80	0.20

¹Statistically significant.

OR: Odds ratio; BMI: Body mass index.