Novel antigen delivery systems

Figure 1 E2 acetyltransferase component from Geobacillus stearothermophilus pyruvate dehydrogenase complex. A: Schematic illustration of the native E2 chain with: lypoil domain (LD), peripheral subunit-binding domain (PSBD), and catalytic acetyltransferase core domain (CD). E2 CD forms trimers that assemble to generate a pentagonal dodecahedral scaffold_(60-mer) with icosahedral symmetry. Trimers are in cyan with monomers of one trimer shown in green, red and blue; B: E2 core from E2DISP acetyltransferase system displaying an antigen of interest (AoI) N-terminally fused to CD; C: Schematic illustration of in vitro refolding of insoluble E2 displaying HIV-1 Envelope V3 in presence of E2 wild-type (E2wt).