Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications

Figure 1 Human leukocyte antigen class I tridimensional structure. Crystal structure of the HLA-B*57:03 (PDB ID: 2YPK); HLA α-chain in gray, β2-microglobulin in blue, the peptide in orange. A: HLA class I overall structure; B: HLA class I peptide binding pocket. In red is shown the HLA pocket B, in green HLA pocket F the most polymorphic regions in HLA peptide binding pocket. The figure has been made using WebLab Viewer Pro 3.7. HLA: Human leukocyte antigen.

Figure 2 Human leukocyte antigen class II tridimensional structure. Crystal structure of the HLA-DR1 (PDB ID: 1DLH) in gray HLA α-chain, in blue HLA β-chain, in orange the peptide. A: HLA class II overall structure; B HLA class II peptide binding pocket. The figure has been made using WebLab Viewer Pro 3.7. HLA: Human leukocyte antigen.

Figure 3 Human leukocyte antigen class I interaction with innate receptor. Crystal structure models of the HLA-B*57:01 interacting respectively with (A): KIR3DL1 receptor (red) (PDB ID: 3HV8); (B): LILRB1 receptor (green). HLA α-chain in gray, β2-microglobulin in blue, the peptide in orange. The figure has been made using WebLab Viewer Pro 3.7. HLA: Human leukocyte antigen.

Figure 4 Peptide recognition. Schematic representation of the contribution of each HLA bound peptide position in the modulation of the interaction between HLA-B molecules (green) with TCR (violet) and KIR3DL1 (yellow), respectively. The figure has been made using WebLab Viewer Pro 3.7. HLA: Human leukocyte antigen; TCR: T cell receptor.