Viral-host molecular interactions and metabolic modulation: Strategies to inhibit flaviviruses pathogenesis

doi:10.5501/wjv.v13.i4.99110

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Dec 25, 2024 (publication date) through Oct 18, 2024

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Dec 25, 2024; 13(4): 99110
Published online Dec 25, 2024. doi: 10.5501/wjv.v13.i4.99110

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Figure 1 Flavivirus structural features. NS: Nonstructural.

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Figure 2 Flavivirus mechanism of infection to host cell. PH: Pondus hydrogenii; DC-Sign: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin.

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Figure 3 Flavivirus-host metabolic interaction and associated therapeutics targets. Protein-protein metabolic interaction, carbohydrate metabolic interaction, lipid metabolic interaction, nucleotide metabolic interaction associated therapeutic strategy. PH: Pondus hydrogenii; DC-Sign: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; FASN: Fatty acid synthase; ATP: Adenosine triphosphate; COA: Coenzyme A; TCA: Tricarboxylic acid; SCD: Sperm chromatin dispersion; SFA: Saturated fatty acid; MUFA: Monounsaturated fatty acid; CPT: Camptothecin; HMG: 3-hydroxy-3-methylglutaryl.

Citation: Khan ZA, Yadav MK, Lim DW, Kim H, Wang JH, Ansari A. Viral-host molecular interactions and metabolic modulation: Strategies to inhibit flaviviruses pathogenesis. World J Virol 2024; 13(4): 99110
URL: https://www.wjgnet.com/2220-3249/full/v13/i4/99110.htm
DOI: https://dx.doi.org/10.5501/wjv.v13.i4.99110