Influence of tacrolimus metabolism rate on renal function after solid organ transplantation

Table 1 Medication doses and blood trough concentrations

	Fast metabolizers (n = 97)	Interm metabolizers (n = 78)	Slow metabolizers (n = 73)	P value
Tacrolimus mean trough level (ng/mL)	8.2 ± 1.6	9.2 ± 1.8	9.5 ± 1.8	< 0.001a
After 1 mo	9.4 ± 3.2	10.5 ± 2.7	11.0 ± 3.2	0.002a
After 3 mo	7.8 ± 2.1	9.1 ± 2.9	9.5 ± 2.8	< 0.001a
After 6 mo	7.2 ± 2.3	7.8 ± 2.4	8.0 ± 2.8	0.079a
Tacrolimus mean daily dose (mg)	11 (6-27)	8 (4-14)	6 (2-12)	< 0.001b
After 1 mo	14 (6-40)	10 (4-22)	8 (2-20)	< 0.001b
After 3 mo	10 (4-23)	7 (4-13)	4 (2-12)	< 0.001b
After 6 mo	9 (3-21)	5 (2-10)	3 (2-8)	< 0.001b
Prednisolon mean daily dose (mg)	15 (4-37)	14 (5-70)	13 (0-40)	0.06b
After 1 mo	20 (15-90)	20 (15-70)	20 (0-50)	0.155b
After 3 mo	14 (3-30)	13 (5-30)	13 (0-30)	0.496b
After 6 mo	10 (5-30)	9 (5-20)	8 (0-20)	0.114b

Tacrolimus (TAC) trough levels and doses and prednisolone doses after renal transplantation. Fast metabolizers revealed noticeable lower TAC trough levels but higher TAC doses compared to intermediate and slow metabolizers. Prednisolone doses did not differ noticeably between the groups.

^aP-value is from the one-way ANOVA;

^bP-value is from the Kruskal-Wallis test; interm., intermediate; modified according to Thölking et al[60].