Recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders

doi:10.5500/wjt.v6.i3.505

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Sep 24, 2016; 6(3): 505-516
Published online Sep 24, 2016. doi: 10.5500/wjt.v6.i3.505

Table 1 Epstein-Barr virus-driven lymphoproliferative disorders are linked with particular Epstein-Barr virus latency programs

Latency	Expressed EBV gene products	Normal B-cell stage	Associated disease
III (growth)	EBER1-2, EBNA1-6, LMP1, LMP2A-B	Activated B lymphoblast	PT-DLBCL AIDS-related lymphoma Acute infectious mononucleosis
II (default)	EBER 1-2, EBNA1, LMP1- 2A	B-cell undergoing the GC reaction	PT-DLBCL Classical Hodgkin lymphoma
I	EBER 1-2 , EBNA1	Memory B-cell	(PT-) Burkitt lymphoma (PT-) PBL

EBER: Epstein-Barr virus-encoded RNA; EBNA: Epstein-Barr virus nuclear antigen; LMP: Latent membrane protein; PT-DLBCL: Post-transplant diffuse large B-cell lymphoma; PBL: Plasmablastic lymphoma; EBV: Epstein-Barr virus.

Citation: Morscio J, Tousseyn T. Recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders. World J Transplant 2016; 6(3): 505-516
URL: https://www.wjgnet.com/2220-3230/full/v6/i3/505.htm
DOI: https://dx.doi.org/10.5500/wjt.v6.i3.505