Copyright
©The Author(s) 2016.
World J Transplant. Mar 24, 2016; 6(1): 144-154
Published online Mar 24, 2016. doi: 10.5500/wjt.v6.i1.144
Published online Mar 24, 2016. doi: 10.5500/wjt.v6.i1.144
Table 1 Comparison of pk parameters of tacrolimus administered as extended release tacrolimus and tacrolimus-BID[12]
| Day 1 | Day 14 | Week 6 | ||||
| PK parameter | Extended release tacrolimus (n = 34) | Tacrolimus-BID (n = 32) | Extended release tacrolimus (n = 34) | Tacrolimus-BID (n = 32) | Extended release tacrolimus (n = 34) | Tacrolimus-BID (n = 32) |
| Mean (SD) | ||||||
| AUC0-24 (ng・h/mL) | 231.91 (102.33) | 361.49 (214.65) | 363.93 (96.61) | 343.69 (105.83) | 331.49 (86.82) | 382.60 (171.22) |
| Cmax (ng/mL) | 18.24 (7.63) | 34.16 (13.86) | 29.87 (9.61) | 31.74 (12.62) | 26.38 (7.30) | 33.04 (13.04) |
| Cmin (ng/mL) | 8.25 (5.01) | 10.12 (6.98) | 9.64 (3.25) | 10.02 (3.04) | 9.60 (2.93) | 12.06 (5.91) |
| Tmax (h) | 4.4 (4.3) | 1.7 (1.0) | 2.4 (1.2) | 1.6 (0.9) | 2.4 (1.3) | 1.9 (1.3) |
| Mean daily dose (mg/kg) | 0.189 | 0.185 | 0.203 | 0.19 | 0.175 | 0.164 |
Table 2 Equivalence comparison of pharmacokinetic parameters after conversion tacrolimus-BID to extended release tacrolimus[19]
| PK parameter | Extended release tacrolimus (n = 60) | Tacrolimus-BID (n = 60) | Ratio (90%CI) extended release tacrolimus: Tacrolimus-BID |
| AUC0-24 (ng・h/mL) | 217.75 | 234.42 | 92.9% (89.9-96.0) |
| Cmax (ng/mL) | 15.99 | 21.84 | 73.2% (67.7-78.7) |
| Cmin (ng/mL) | 6.60 | 7.26 | 90.9% (87.3-94.6) |
- Citation: Patel N, Cook A, Greenhalgh E, Rech MA, Rusinak J, Heinrich L. Overview of extended release tacrolimus in solid organ transplantation. World J Transplant 2016; 6(1): 144-154
- URL: https://www.wjgnet.com/2220-3230/full/v6/i1/144.htm
- DOI: https://dx.doi.org/10.5500/wjt.v6.i1.144