Observational Study
Copyright ©The Author(s) 2015.
World J Transplant. Dec 24, 2015; 5(4): 329-337
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.329
Table 1 Patient characteristics
ABOi (n = 30)ABOc (n = 30)P-value
Recipient age (yr)39 ± 11 (16-60)37 ± 11 (19-64)ns
Donor age (yr)59 ± 9 (42-77)61 ± 11 (41-78)ns
Recipient gender female/male8/227/23ns
Donor gender female/male24/619/11ns
HLA mismatches2.7 ± 1.22.4 ± 1.2ns
PRAs > 10%33ns
Time on dialysis (mo)37 ± 34 (4-132)19 ± 18 (0-82)0.014a
ABOi
A-O12 (40%)
B-O4 (13.3%)
A-B2 (6.7%)
B-A1 (3.3%)
AB-A5 (16.7%)
AB-B6 (20%)
Anti-A/B IgG titer at referral (median)1:64 (1:1-1:128)
No. of pretransplant IA5.1 ± 3.1 (0-14)
No. of posttrasplant IA3.3 ± 1.4 (1-7)
Cause of renal failure
Polycystic disease6 (20%)1 (3.3%)
Hypertension1 (3.3%)1 (3.3%)
Glumerulonephritis8 (26.7%)5 (16.7%)
Genetic disorder3 (10%)4 (13.3%)
Diabetes3 (10%)1 (3.3%)
Unknown6 (20%)16 (53.4%)
Other3 (10%)2 (6.7%)
Table 2 Graft function, rejection episodes after kidney transplantation
ABOi (n = 30)ABOc (n = 30)P-value
Mean follow-up (mo)74 (14-114)78 (13-116)ns
Serum creatinine (mg/dL)
1 yr after KTx1.56 ± 0.341.53 ± 0.46ns
3 yr after KTx1.53 ± 0.371.5 ± 0.43ns
5 yr after KTx1.6 ± 0.481.53 ± 0.55ns
8 yr after KTx1.78 ± 0.571.76 ± 0.58ns
eGFR by MDRD (mL/min per 1.73 m2)
1 yr after KTx56.1 ± 13.456.3 ± 16.8ns
3 yr after KTx51.5 ± 17.156.1 ± 16.1ns
5 yr after KTx53.1 ± 1754.5 ± 17.3ns
8 yr after KTx47.3 ± 20.544.4 ± 16.4ns
Rejections
Acute cellular rejection 4 (13.3%)3 (10%)ns
Acute antibody - mediated rejection0 (0%)0 (0%)ns
Table 3 Histological findings n (%)
Patients with biopsiesABOi (n = 18)ABOc (n = 13)P-value
Acute tubular injury2 (11)3 (23)ns
Acute cellular rejection4 (22)3 (23)ns
Endarteritis1 (6)0 (0)ns
Acute cellular rejection < 1 yr post transplantation4 (22)2 (15)ns
Acute cellular rejection > 1 yr post transplantation0 (0)1 (8)ns
Acute antibody - mediated rejection with histological signs0 (0)0 (0)ns
Chronic antibody - mediated rejection, C4d (+)0 (0)2 (15)ns
Chronic antibody - mediated rejection, C4d (+) < 1 yr post transplantation without TGL0 (0)1 (8)ns
Chronic antibody - mediated rejection, C4d (+) > 1 yr post transplantation with TGL0 (0)1 (8)ns
C4d+ in peritubular capillaries9 (50)2 (15)ns
CNI toxicity1 (6)1 (8)ns
BK nephropathy4 (22)1 (8)ns
Primary disease recurrence1 (6)2 (15)ns
IF/TA with no evidence of any specific etiology2 (11)1 (8)ns
No findings4 (22)2 (15)ns
Table 4 Surgical and infectious complication n (%)
ABOiABOcP-value
(n = 30)(n = 30)
Surgical complications
Lemphocele4 (13.3)1 (3.3)ns
Other2 (6.7)2 (6.7)ns
Infectious complications
Bacterial (requiring hospitalization)15 (50)17 (56.7)ns
Bacteraemia5 (16.7)4 (13.3)ns
CMV1 (3.3)1 (3.3)ns
BKV5 (16.7)2 (6.7)ns