Melexopoulou C, Marinaki S, Liapis G, Skalioti C, Gavalaki M, Zavos G, Boletis JN. Excellent long term patient and renal allograft survival after ABO-incompatible kidney transplantation: Experience of one center. World J Transplant 2015; 5(4): 329-337 [PMID: 26722661 DOI: 10.5500/wjt.v5.i4.329]
Corresponding Author of This Article
Christina Melexopoulou, MD, Nephrology Department and Renal Transplantation Unit, Laiko Hospital, 17 Ag., Thoma Street, 11527 Athens, Greece. xmelexopoulou@yahoo.gr
Research Domain of This Article
Transplantation
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 2 Graft function, rejection episodes after kidney transplantation
ABOi (n = 30)
ABOc (n = 30)
P-value
Mean follow-up (mo)
74 (14-114)
78 (13-116)
ns
Serum creatinine (mg/dL)
1 yr after KTx
1.56 ± 0.34
1.53 ± 0.46
ns
3 yr after KTx
1.53 ± 0.37
1.5 ± 0.43
ns
5 yr after KTx
1.6 ± 0.48
1.53 ± 0.55
ns
8 yr after KTx
1.78 ± 0.57
1.76 ± 0.58
ns
eGFR by MDRD (mL/min per 1.73 m2)
1 yr after KTx
56.1 ± 13.4
56.3 ± 16.8
ns
3 yr after KTx
51.5 ± 17.1
56.1 ± 16.1
ns
5 yr after KTx
53.1 ± 17
54.5 ± 17.3
ns
8 yr after KTx
47.3 ± 20.5
44.4 ± 16.4
ns
Rejections
Acute cellular rejection
4 (13.3%)
3 (10%)
ns
Acute antibody - mediated rejection
0 (0%)
0 (0%)
ns
Table 3 Histological findings n (%)
Patients with biopsies
ABOi (n = 18)
ABOc (n = 13)
P-value
Acute tubular injury
2 (11)
3 (23)
ns
Acute cellular rejection
4 (22)
3 (23)
ns
Endarteritis
1 (6)
0 (0)
ns
Acute cellular rejection < 1 yr post transplantation
4 (22)
2 (15)
ns
Acute cellular rejection > 1 yr post transplantation
0 (0)
1 (8)
ns
Acute antibody - mediated rejection with histological signs
0 (0)
0 (0)
ns
Chronic antibody - mediated rejection, C4d (+)
0 (0)
2 (15)
ns
Chronic antibody - mediated rejection, C4d (+) < 1 yr post transplantation without TGL
0 (0)
1 (8)
ns
Chronic antibody - mediated rejection, C4d (+) > 1 yr post transplantation with TGL
0 (0)
1 (8)
ns
C4d+ in peritubular capillaries
9 (50)
2 (15)
ns
CNI toxicity
1 (6)
1 (8)
ns
BK nephropathy
4 (22)
1 (8)
ns
Primary disease recurrence
1 (6)
2 (15)
ns
IF/TA with no evidence of any specific etiology
2 (11)
1 (8)
ns
No findings
4 (22)
2 (15)
ns
Table 4 Surgical and infectious complication n (%)
ABOi
ABOc
P-value
(n = 30)
(n = 30)
Surgical complications
Lemphocele
4 (13.3)
1 (3.3)
ns
Other
2 (6.7)
2 (6.7)
ns
Infectious complications
Bacterial (requiring hospitalization)
15 (50)
17 (56.7)
ns
Bacteraemia
5 (16.7)
4 (13.3)
ns
CMV
1 (3.3)
1 (3.3)
ns
BKV
5 (16.7)
2 (6.7)
ns
Citation: Melexopoulou C, Marinaki S, Liapis G, Skalioti C, Gavalaki M, Zavos G, Boletis JN. Excellent long term patient and renal allograft survival after ABO-incompatible kidney transplantation: Experience of one center. World J Transplant 2015; 5(4): 329-337