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©2014 Baishideng Publishing Group Co.
World J Transplant. Mar 24, 2014; 4(1): 30-39
Published online Mar 24, 2014. doi: 10.5500/wjt.v4.i1.30
Published online Mar 24, 2014. doi: 10.5500/wjt.v4.i1.30
Table 1 Clinically available immune monitoring after adult liver transplantati
Sensitivity | Specificity | |
Currently available | ||
Liver biochemistry | High | Low |
Therapeutic drug levels | Low | Low |
ImmuKnow | Low | High |
Liver histology | Gold standard | Gold standard |
Future possibilities | ||
PlexImmune | Only Paedeatric studies published | |
? Combination assays |
Table 2 Summary of assays for immune function monitoring
Advantages | Disadvantages | ||
Antigen-specific assays: | Limiting dilution aAssays, mixed lymphocyte reactions, ELISPOT | Measure individual antigen specific response | Need donor cells, Laboratory intensive |
Antigen non-specific: | ImmuKnow | Available, FDA approved | Inconsistent results |
Cytokine levels/polymorphisms | Inconsistent results | ||
Immune competence scores | Readily available | Lack of published validation studies | |
Regulatory T cells (Tregs) | Associated with rejection | Laboratory intensive. Lack of published validation studies | |
Soluble CD30 | Lack of association with clinical outcomes in OLTx | ||
Identifying operational tolerant recipients: | Tregs, Gene expression, dendritic cell types, delayed type hypersensitivity | Able to identify recipients in whom immunosuppression could be withdrawn | Laboratory intensive. Only few recipients suitable |
- Citation: Sood S, Testro AG. Immune monitoring post liver transplant. World J Transplant 2014; 4(1): 30-39
- URL: https://www.wjgnet.com/2220-3230/full/v4/i1/30.htm
- DOI: https://dx.doi.org/10.5500/wjt.v4.i1.30