Review
Copyright ©2012 Baishideng.
World J Transplant. Dec 24, 2012; 2(6): 95-103
Published online Dec 24, 2012. doi: 10.5500/wjt.v2.i6.95
Table 1 Causes of intestinal failure in children
AtresiaNecrotizing enterocolitis
Midgut volvulusArterial thrombosis
Abdominal wall defectsVenous Thrombosis
GastrochisisIntussusception
OmpaloceleInflamatory bowel disease
Hirschsprung’s diseasePost traumatic resection
Table 2 Indications for bowel transplantation in children and adults
ChildrenAdults
GastroschisisIschemia
VolvulusCrohn’s disease
Necrotizing enterocolitisTrauma
PseudoobstructionVolvulus
Intestinal atresiaMotility disorders
Aganglionosis/HirschsprungDesmoids
RetransplantRetransplant
Microvillous inclusionMiscellaneous
MalabsorptionGardner’s syndrome
Tumors
Table 3 Contraindications to small bowel transplant
Absolute contraindications
Neurological disabilities
Life threatening disease unrelated to the digestive system
Non-resectable malignancy
Relative contraindications
Severe immunological deficiencies
Multi-system autoimmune diseases
Inadequate vascular anatomy to warrant long term patency
Prematurity with lung disease
Table 4 Histological characteristics of acute rejection of intestinal graft
Mild> 6 apoptotic bodies/10 crypts, no mucosal ulceration, mild epithelial injury
ModerateDiffuse crypt epithelial injury, focal confluent apoptosis, intimal arteritis
SevereMucosal ulceration, transmural arteritis