Retrospective Cohort Study
Copyright ©The Author(s) 2024.
World J Transplant. Sep 18, 2024; 14(3): 95233
Published online Sep 18, 2024. doi: 10.5500/wjt.v14.i3.95233
Table 1 Recipient demographics for paired kidneys transplanted first (kidney 1 group) and second (kidney 2 group, with longer hypothermic machine perfusion time)
Characteristics
Received kidney 1 (n = 61)
Received kidney 2 (n = 61)
P value
Age (years, 95%CI)52.2 (48.8, 55.4)53.3 (49.8, 56.7)0.64
Sex (M:F)42:1942:191.0
Weight (kg, 95%CI)82.1 (77.4, 86.7)80.8 (76.2, 85.5)0.71
Height (cm, 95%CI)173 (170, 175)171 (168, 173)0.28
BMI (kg/m2, 95%CI)27.4 (26.1, 28.7)27.6 (26.3, 28.9)0.79
Diabetes (%)20 (33)15 (25)0.32
HSP (%)3 (5)3 (5)1.0
Average HLA mismatches (95%CI)6.3 (5.9, 6.7)6.4 (6, 6.85)0.65
Retransplant (%)5 (8)5 (8)1.0
Time on dialysis prior to transplant (months, IQR)47 (27, 60)48 (33, 64)0.22
BMI: Body mass index; HSP: Highly sensitized patient; CI: Confidence interval; HLA: Human leukocyte antigen.
Table 2 Donor kidney factors for paired kidneys transplanted first (kidney 1 group) and second (kidney 2 group, with longer hypothermic machine perfusion time)
Factor
Received kidney 1 (n = 61)
Received kidney 2 (n = 61)
P value
DCDD (%)42 (69)42 (69)1.0
ECD (%)19 (31)19 (31)1.0
HMP time (HR, 95%CI)5.2 (4.5, 5.8)10.8 (9.9, 11.7)< 0.0001b
Static cold storage time (HR, 95%CI)3.7 (3.1, 4.3)3.9 (3.1, 4.7)0.38
Total CIT (HR, 95%CI)8.9 (7.9, 9.8)14.7 (13.7, 15.8)< 0.0001b
WIT2 (min, 95%CI)52 (47, 57)53(48, 59)0.81
bP < 0.01.
ECD: Expanded criteria donation; CIT: Cold ischemic time; DCDD: Donation after circulatory determination of death; HMP: Hypothermic machine perfusion; WIT2: Warm ischemic time at the time of anastomosis; CI: Confidence interval.