Innovative immunosuppression in kidney transplantation: A challenge for unmet needs

Table 1 Therapies targeting delayed graft function in kidney transplantation

Drug	Molecular target	Mechanism of action
15NP or QPI-1002	p53	Inhibition of apoptosis
Pegylated carboxyhemoglobin	Cytochrome C oxidase; cytochrome P450; HMGB-1; P38 MAPK pathway	Inhibition of oxidative injury, inflammation, and apoptosis
Relaxin	ICAM-1; neutrophil adhesion	Vasodilatation; inhibition of apoptosis
ANG-3777 (BB3)	Tyrosine kinase receptor cMET	Antinflammation; inhibition of epithelial to mesenchymal transition
Mirocept (APT 070)	Inhibition of C3/C5 convertase	Inhibition of complement activation
C1 esterase inhibitor	C1 esterase	Inhibition of complement activation

HMGB-1: High mobility group protein box-1; MAPK: Mitogen-activated protein kinases; ICAM 1: Intercellular adhesion molecule 1.