Recent progress in pancreatic islet transplantation

Table 1 Criteria for clinical islet transplantation in Japan

Inclusion criteria

< 75 yr of age

Undetectable C-peptide levels (< 0.1 ng/mL)

Duration of type 1 diabetes mellitus for > 5 yr accompanied by recurrent neuroglycopenia

Reduced awareness of hypoglycemic episodes and/or severe glycemic lability despite intensive insulin therapy and glycemic monitoring

Exclusion criteria

Presence of uncorrectable coronary disease

A body mass index of > 25 kg/m2

Inadequate renal reserve defined as serum creatinine level of > 1.5 mg/dL, creatinine clearance of < 80 mL/min per 1.73 m2 of body surface area, or a urinary albumin level of > 300 mg/24 h

Negative serological findings for Epstein-Barr virus at the time of assessment