Peripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy?

Figure 1 Correlation of harvested CD34⁺ cells counts with white blood cell count and peripheral blood CD34⁺ cell count. A: Correlation of harvested CD34⁺ cells counts with white blood cell count; B: Correlation of harvested CD34⁺ cells counts with peripheral blood CD34⁺ cell count. Reprinted by permission from Macmillan Publishers Ltd: Bone Marrow Transplant 1997[16]. http://www.nature.com/bmt/index.html.

Figure 2 Bone marrow microenvironment (A) at physiologic state and effects of (B) granulocyte colony stimulating factor mobilization and (C) Plerixafor mobilization. Reprinted from Journal of Cellular Biochemistry, Vol 99/edition 3, Bruno Nervi, Dan C. Link, John F DiPersio, Cytokines and Hematopoietic Stem Cell Mobilization, 690-705, 2010, with permission from Wiley[26]. G-CSF: Granulocyte colony stimulating factor; HSC: Hematopoietic stem cell; SDF-1: Stromal cell-derived factor-1; VCAM-1: Vascular cell adhesion molecule.

Figure 3 Mobilization strategies at authors’ institution. CM: Chemomobilization; G-CSF: Granulocyte colony stimulating factor.