Influence of tacrolimus metabolism rate on renal function after solid organ transplantation

Figure 1 Morphological changes of cells undergoing epithelial to mesenchymal transformation. Images from atomic force microscopy of glutardialdehyde fixed cells in fluid (highest sample areas are represented in white). A: Typically, epithelial tubular cells (NRK-52E), (50 μm)², appear with numerous microvillus compatible structures on the cellular surface; B: Tubular cells after six days of TGF-β1 treatment (50 μm)². Cells show a fibrillary surface structure with rarefied microvilli. Nodular protrusions developed at the cell borders (black arrows)[35]. ©IOP Publishing. Reproduced with permission. All rights reserved. TGF: Transforming growth factor.

Figure 2 Estimated renal function measured by estimated glomerular filtration rate (Cockcroft-Gault eGFR, mL/min) after liver transplantation. There was no noticeable difference between fast and slow tacrolimus metabolizers at liver transplantation at 1 mo or 3 mo after liver transplantation. After 6, 12, and 36 mo, slow tacrolimus metabolizers had a significantly better renal function than fast metabolizers. Mean estimates and corresponding 95% confidence intervals from the multivariable linear mixed model are plotted; overlapping areas are shown in dark grey[59]. eGFR: Estimated glomerular filtration rate.