Imaging-based diagnosis of acute renal allograft rejection

Figure 1 Representative ultrasound images of an allogeneically transplanted (aTX) rat kidney (graft) and its native control kidney (native) on day 4 post surgery. Depicted are examples of transversal images taken before (pre CM) and 15 min after (post CM) tail vein injection of anti-CD3-antibody labeled microbubbles. CM: Contrast media/microbubbles conjugated to anti CD3 antibody.

Figure 2 Representative positron emission tomography-images of dynamic whole body acquisitions of a series of an allogeneically transplanted rat [postoperative day 1 (A), 2 (B), 4 (C), and 7 (D)], after tail vein injection of 30 MBq ¹⁸F-fluordeoxyglucose (maximum a posterior projection, 180 min pi). While the allograft undergoing rejection shows distinct enhancement of ¹⁸F-FDG (yellow circle) the native control kidney without rejection does not (green circles). Figure taken from[44]. POD: Postoperative day; FDG: Fluordeoxyglucose.