Clinical and pathological features of kidney transplant patients with concurrent polyomavirus nephropathy and rejection-associated endarteritis

Figure 1 Diagnostic features of acute rejection from biopsies with concurrent polyomavirus nephropathy. Representative images of (A) nuclear inclusions characteristic of polyomavirus cytopathic effect (hematoxylin and eosin) and nuclear large-T antigen staining (inset, highlighted in brown) and (B) intimal arteritis (v1 by Banff criteria), as demonstrated by lymphocytes undermining the endothelium (white arrow).

Figure 2 Creatinine trends after identification of concurrent acute rejection and polyomavirus nephropathy. Serum creatinine values are depicted relative to the baseline creatinine at 1, 3, 6 and 12 mo following the index biopsy. Patients with a prior decrease of IS are represented by solid lines and squares. Patients with no known change of IS are represented by dashed lines and circles. ^aNephrectomy at 144 d; ^bNephrectomy at 483 d; ^cClinical graft loss at 1 year. IS: Immunosuppression.