Immunotherapy and liver transplantation for hepatocellular carcinoma: Current and future challenges

doi:10.5500/wjt.v15.i2.98509

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Jun 18, 2025 (publication date) through Feb 21, 2025

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 18, 2025; 15(2): 98509
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.98509

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Figure 1 Immunotherapy landscape of hepatocellular carcinoma. An overview of various immunotherapeutic agents under investigation for the treatment of hepatocellular carcinoma. AFP: Alpha-fetoprotein; CAR-T: Chimeric antigen receptor expressing T cell; CIK: Cytokine-induced killer; CTLA-4: Cytotoxic T-lymphocyte associated antigen 4; DC: Dendritic cell; GPC3: Glypican-3; LAG-3: Lymphocyte activation gene 3; MRP3: Multidrug resistance-associated protein 3; NK: Natural killer; PD-1: Programmed cell death protein 1; PD-L1: Programmed cell death ligand 1; TGF-β: Transforming growth factor-β; Tim-3: T-cell immunoglobulin and mucin-domain containing-3.

Citation: Pettas T, Lachanoudi S, Karageorgos FF, Ziogas IA, Fylaktou A, Papalois V, Katsanos G, Antoniadis N, Tsoulfas G. Immunotherapy and liver transplantation for hepatocellular carcinoma: Current and future challenges. World J Transplant 2025; 15(2): 98509
URL: https://www.wjgnet.com/2220-3230/full/v15/i2/98509.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i2.98509