Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome

Table 1 Candidate peptides with structural and functional similarity to the phospholipid-binding region of domain V of beta-2 glycoprotein I

Peptide	Source	Amino acid sequence	Inhibition of β2GPI binding to CL (%)1
GDKV	Gly274-Cys288 in domain V of human B2GPI	GDKVSFFCKNKKC	43
GDKV2	Modified GDKV with all six residues between Lys282-Lys287 replaced with Lys	GDKVSFFCKKKKKKC	56
TADL	Thr77-Glu96 of Adv type2 DNA binding protein	TADLAIASKKKKKRPSPKPE	68
TIFI	Thr101-Thr120 of ULB0-HCMVA from human CMV	TIFILFCCSKEKRKKKQAAT	75
VITT	Val51-Ile70 of US27-HCMVA from human CMV	VITTILYYRRKKKSPSDT	83
SGDF	Ser237-Ser256 of TLP-BACSU from Bacillus subtilis	SGDFEYTYKGKKKKMAFATS	NA

¹Refers to the percentage of inhibition of 100 nmol/L of beta-2 glycoprotein I binding to cardiolipin produced by 6uM of each peptide. CMV: Cytomegalovirus; NA: Not available; β₂GPI: Beta-2 glycoprotein I; CL: Cardiolipin.